公开(公告)号：US20240344138A1

公开(公告)日：2024-10-17

申请号：US18552410

申请日：2022-03-24

申请人： Feng Biosciences, Inc

发明人： Laura E. BENJAMIN ,  Kristen STRAND-TIBBITTS ,  Rafael ROSENGARTEN ,  Miha ŠTAJDOHAR ,  Robert CVITKOVIC

IPC分类号： C12Q1/6886 ,  A61K45/00 ,  G16B25/10 ,  G16H50/20

CPC分类号： C12Q1/6886 ,  A61K45/00 ,  G16B25/10 ,  G16H50/20 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The disclosure provides methods to categorize cancers and cancer patients using a classifier, TME Panel-1, which stratifies patients and cancers according to tumor microenvironments. Treatment decisions are then guided by the presence/absence of a particular TME phenotype class. Also provided are methods for treating a subject, e.g., a human subject, afflicted with gastric cancer, breast cancer, prostate cancer, liver cancer, carcinoma of head and neck, melanoma, colorectal cancer, or ovarian cancer comprising administering a particular therapy depending on the classification of the cancer's TME according to the TME Panel-1 classifier. Also provided are personalized treatments that can be administered to patients depending on the TME Panel-1 classification of a particular type of cancer, e.g., left or right colorectal cancer or dMMR colorectal cancer.