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    Tissue site markers for in vivo imaging
    2.
    发明申请
    Tissue site markers for in vivo imaging 有权
    用于体内成像的组织位点标记

    公开(公告)号：US20050063908A1

    公开(公告)日：2005-03-24

    申请号：US10658911

    申请日：2003-09-10

    申请人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Richard Quick ,  Frank Louw ,  Stephen De Santis

    发明人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Richard Quick ,  Frank Louw ,  Stephen De Santis

    IPC分类号： A61B6/00 ,  A61B6/12 ,  A61B8/08 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B19/00 ,  A61K49/00 ,  A61K49/04 ,  A61K49/22

    CPC分类号： A61M37/0069 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/08021 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3987 ,  A61K49/006 ,  A61K49/222

    摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

    摘要翻译： 本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。 本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。 本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。 标记可以具有不均匀的表面轮廓以增强声学特征。 标记具有在医学成像期间可识别人造的特征形式。 可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

    Devices and methods for occlusion of the uterine arteries
    9.
    发明授权
    Devices and methods for occlusion of the uterine arteries 失效
    用于闭塞子宫动脉的装置和方法

    公开(公告)号：US07771357B2

    公开(公告)日：2010-08-10

    申请号：US10459342

    申请日：2003-06-10

    申请人： Fred Burbank ,  Michael Jones ,  Paul Lubock

    发明人： Fred Burbank ,  Michael Jones ,  Paul Lubock

    IPC分类号： A61B8/00 ,  A61B5/05 ,  A61B17/08

    CPC分类号： A61B8/12 ,  A61B8/06 ,  A61B8/0833 ,  A61B17/12013 ,  A61B17/42 ,  A61B18/1485

    摘要： Devices and methods are disclosed for treating a uterine disorder which receive its blood supply from a uterine artery. In particular, uterine fibroids are effectively treated by occluding the uterine arteries using trans-vaginal, trans-uterine, transrectal, or retroperitoneal approaches. The devices and methods are advantageous because the inventive procedures may be performed by a patient's gynecologist in the course of treatment, avoiding the need for referrals to specialist practitioners and for more radical treatments, such as hysterectomies. The methods include both temporary and permanent occlusion of the arteries. A cannula carries an imaging device and a member which will easily penetrate tissue, the member including a device which partially or completely, and temporarily or permanently, occludes a uterine artery.

    摘要翻译： 公开了用于治疗从子宫动脉接受其血液供应的子宫疾病的装置和方法。 特别地，子宫肌瘤通过使用经阴道，经子宫，经直肠或腹膜后方法闭塞子宫动脉来有效治疗。 所述装置和方法是有利的，因为本发明的方法可以由患者的妇科医生在治疗过程中进行，避免需要转诊给专科医师，以及进行诸如子宫切除术等更激进的治疗。 这些方法包括动脉的临时和永久闭塞。 套管携带成像装置和容易穿透组织的构件，该构件包括部分地或完全地暂时地或永久地阻塞子宫动脉的装置。

    Imageable biopsy site marker
    10.
    发明申请
    Imageable biopsy site marker 审中-公开
    可成像的活检部位标记

    公开(公告)号：US20060155190A1

    公开(公告)日：2006-07-13

    申请号：US11366956

    申请日：2006-03-02

    申请人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Nancy Forcier

    发明人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Nancy Forcier

    IPC分类号： A61B6/00

    CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2090/3788 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61M37/0069

    摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by an delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

    摘要翻译： 活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。 具有不透射线物体的至少一个生物可再吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。 将管的一端放入活检部位。 至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。 至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像 导入后的第二时间点（如5-7个月）附近的组织组织。