公开(公告)号：US20190175749A1

公开(公告)日：2019-06-13

申请号：US16271549

申请日：2019-02-08

Applicant: GENENTECH, INC.

Inventor： Peter DRAGOVICH ,  Zhonghua PEI ,  Thomas PILLOW ,  Jack SADOWSKY ,  Vishal VERMA ,  Donglu ZHANG

IPC: A61K47/68 ,  A61P35/00 ,  A61K31/5517

Abstract: The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.

公开(公告)号：US20200085965A1

公开(公告)日：2020-03-19

申请号：US16689286

申请日：2019-11-20

Applicant: GENENTECH, INC.

Inventor： Peter DRAGOVICH ,  Zhonghua PEI ,  Thomas PILLOW ,  Jack SADOWSKY ,  Vishal VERMA ,  Donglu ZHANG

IPC: A61K47/68 ,  A61K31/5517 ,  A61P35/00

Abstract: The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.