公开(公告)号：US20030091561A1

公开(公告)日：2003-05-15

申请号：US10172317

申请日：2002-06-13

Applicant: GENMAB A/S

Inventor： Jan G.J. van de Winkel ,  Marcus A. van Dijk ,  Arnout F. Gerritsen ,  Edward Halk

IPC: A61K039/395 ,  C12N005/06 ,  C07K016/28

CPC classification number: C07K16/2863 ,  A01K2217/05 ,  A01K2217/075 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/732

Abstract: Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.