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公开(公告)号：US20240091352A1
公开(公告)日：2024-03-21
申请号：US18175894
申请日：2023-02-28
Applicant: GENMAB A/S
Inventor： Esther BREIJ , David SATIJN , Edward Norbert VAN DEN BRINK , Dennis VERZIJL , Rob N. DE JONG , Paul PARREN , Riemke VAN DIJKHUIZEN RADERSMA
IPC: A61K39/395 , A61K47/68 , C07K16/28 , C07K16/30
CPC classification number: A61K39/39558 , A61K47/6801 , A61K47/6855 , A61K47/6857 , A61K47/6869 , C07K16/2863 , C07K16/3061 , A61K2039/505
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US20230076417A1
公开(公告)日：2023-03-09
申请号：US17714735
申请日：2022-04-06
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Joost MELIS , Tom VINK , Hendrik TEN NAPEL , Esther BREIJ , David SATIJN , Paul PARREN
Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−9 and 10−8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
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公开(公告)号：US20190275149A1
公开(公告)日：2019-09-12
申请号：US16248402
申请日：2019-01-15
Applicant: GENMAB A/S
Inventor： Esther BREIJ , David SATIJN , Edward Norbert VAN DEN BRINK , Dennis VERZIJL , Rob N. DE JONG , Paul PARREN , Riemke VAN DIJKHUIZEN RADERSMA
IPC: A61K39/395 , C07K16/28 , C07K16/30 , A61K47/68
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US20190022243A1
公开(公告)日：2019-01-24
申请号：US16069395
申请日：2017-01-13
Applicant: GENMAB A/S
Inventor： Julia BOSHUIZEN , Esther BREIJ , Louise KOOPMAN , David SATIJN , Edward VAN DEN BRINK , Dennis VERZIJL , Rob DE JONG , Riemke VAN DIJKHUIZEN RADERSMA , Daniel PEEPER , Paul PARREN
Abstract: Antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of melanoma in combination with one or more MAPK pathway inhibitors such as, e.g., a BRAF inhibitor and/or a MEK inhibitor.
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公开(公告)号：US20180214549A1
公开(公告)日：2018-08-02
申请号：US15938961
申请日：2018-03-28
Applicant: GENMAB A/S
Inventor： Esther BREIJ , David SATIJN , Edward Norbert VAN DEN BRINK , Dennis VERZIJL , Rob N. DE JONG , Paul PARREN , Riemke VAN DIJKHUIZEN RADERSMA
IPC: A61K39/395 , C07K16/30
CPC classification number: A61K39/39558 , A61K47/6801 , A61K47/6855 , A61K47/6857 , A61K47/6869 , A61K2039/505 , A61K2121/00 , C07K16/2863 , C07K16/3061 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/77 , C07K2317/92
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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Patent Agency Ranking
公开(公告)号：US20230321261A1
公开(公告)日：2023-10-12
申请号：US17957302
申请日：2022-09-30
Applicant: GENMAB A/S
Inventor： Julia BOSHUIZEN , Esther BREIJ , Louise KOOPMAN , David SATIJN , Edward VAN DEN BRINK , Dennis VERZIJL , Rob DE JONG , Riemke VAN DIJKHUIZEN RADERSMA , Daniel PEEPER , Paul PARREN
CPC classification number: A61K47/6803 , A61K39/001102 , A61K45/06 , A61K47/6801 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6869 , A61P35/00 , C07K16/2863 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/77 , C07K2317/92
Abstract: Antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of melanoma in combination with one or more MAPK pathway inhibitors such as, e.g., a BRAF inhibitor and/or a MEK inhibitor.
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公开(公告)号：US20200171152A1
公开(公告)日：2020-06-04
申请号：US16673383
申请日：2019-11-04
Applicant: GENMAB A/S
Inventor： Esther BREIJ , David SATIJN , Edward Norbert VAN DEN BRINK , Dennis VERZIJL , Rob N. DE JONG , Paul PARREN , Riemke VAN DIJKHUIZEN RADERSMA
IPC: A61K39/395 , C07K16/28 , A61K47/68 , C07K16/30
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US20190352423A1
公开(公告)日：2019-11-21
申请号：US16072437
申请日：2017-02-03
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Joost MELIS , Tom VINK , Hendrik TEN NAPEL , Esther BREIJ , David SATIJN , Paul PARREN
Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−9 and 10−8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
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公开(公告)号：US20170157250A1
公开(公告)日：2017-06-08
申请号：US15325364
申请日：2015-07-10
Applicant: GENMAB A/S
Inventor： Esther BREIJ , David SATIJN , Edward Norbert VAN DEN BRINK , Dennis VERZIJL , Rob N. DE JONG , Paul PARREN , Riemke VAN DIJKHUIZEN RADERSMA
IPC: A61K39/395 , C07K16/30
Abstract: The present disclosure relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US20210393793A1
公开(公告)日：2021-12-23
申请号：US17279359
申请日：2019-09-26
Applicant: GENMAB A/S
Inventor： Esther BREIJ , Ulf FORSSMANN , Tahamtan AHMADI
Abstract: The present invention relates to immunoconjugates anti-AXL antibodies and compositions for treatment of non-small cell lung cancer.
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