公开(公告)号：US09458236B2

公开(公告)日：2016-10-04

申请号：US14055222

申请日：2013-10-16

Applicant: GENMAB A/S

Inventor： Jan G. J. Van De Winkel ,  Marcus Antonius Van Dijk ,  Edward Halk ,  Arnout F. Gerritsen ,  Jørgen Petersen ,  Ole Baadsgaard

IPC: A61K39/395 ,  C07K16/28 ,  C07H21/04 ,  G01N33/53 ,  A61K45/06 ,  A61K47/48 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A01K2217/05 ,  A01K2217/075 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56966

Abstract: Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.