公开(公告)号：US10882913B2

公开(公告)日：2021-01-05

申请号：US16451714

申请日：2019-06-25

Applicant: GENMAB B.V.

Inventor： Marije Overdijk ,  Kristin Strumane ,  Rik Rademaker ,  Esther Breij ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/28 ,  C07K16/30 ,  C12N15/10 ,  A61P35/00 ,  C12N15/62 ,  A61K39/00 ,  C07K16/46 ,  A61K38/00

Abstract: The present invention relates to monospecific or bispecific antibody molecules that specifically bind the human DR5 antigen. The invention relates in particular to DR5-specific antibody molecules of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding leading to the induction of DR5 signaling, apoptosis and cell death. The invention further relates to a combination of antibody molecules binding different epitopes on DR5. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these compositions.

公开(公告)号：US12247080B2

公开(公告)日：2025-03-11

申请号：US17108373

申请日：2020-12-01

Applicant: GENMAB B.V.

Inventor： Marije Overdijk ,  Kristin Strumane ,  Rik Rademaker ,  Esther Breij ,  Janine Schuurman ,  Paul Parren

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C12N15/62 ,  A61K38/00 ,  A61K39/00 ,  C07K14/715 ,  C07K16/46

Abstract: The present invention relates to monospecific or bispecific antibody molecules that specifically bind the human DR5 antigen. The invention relates in particular to DR5-specific antibody molecules of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding leading to the induction of DR5 signalling, apoptosis and cell death. The invention further relates to a combination of antibody molecules binding different epitopes on DR5. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these compositions.

公开(公告)号：US12173076B2

公开(公告)日：2024-12-24

申请号：US16482747

申请日：2018-02-12

Applicant: GENMAB B.V.

Inventor： Frank Beurskens ,  Marije Overdijk ,  Annieck M. Diks ,  Rob De Jong ,  Kristin Strumane ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/28 ,  C07K16/10

Abstract: As described herein are polypeptides and antibodies having an Fc region and an antigen binding region where the Fc region has an Fc-Fc-enhancing mutation and a C1q binding-enhancing mutation providing for polypeptides or antibodies with increased CDC activity and/or agonistic activity.