公开(公告)号：US20220411876A1

公开(公告)日：2022-12-29

申请号：US17687536

申请日：2022-03-04

Applicant: GUARDANT HEALTH, INC.

Inventor： Katie Julia QUINN ,  Allysia Jade MAK ,  Elena HELMAN ,  Tingting JIANG ,  Justin I. ODEGAARD ,  Darya CHUDOVA ,  Kyle Lik Ming CHANG ,  Han-Yu CHUANG ,  Daniel GAILE

IPC: C12Q1/6886 ,  G16B30/00 ,  G16B40/00

Abstract: Provided herein are methods of determining a molecular response score. The molecular response score may be used to monitor and guide administration of treatment to a subject.

公开(公告)号：US20240412815A1

公开(公告)日：2024-12-12

申请号：US18545747

申请日：2023-12-19

Applicant: GUARDANT HEALTH, INC.

Inventor： Catalin BARBACIORU ,  Daniel GAILE

IPC: G16B20/20 ,  G06N5/022 ,  G16B40/20

Abstract: In implementations described herein, methylation information is determined with respect to classification regions of a reference genome that are related to the presence of a homologous recombination repair deficiency in a subject. The methylation information can be analyzed using a number of computational techniques to provide metrics related to the presence or absence of a homologous recombination repair deficiency in a given subject.

公开(公告)号：US20220344004A1

公开(公告)日：2022-10-27

申请号：US17691049

申请日：2022-03-09

Applicant: GUARDANT HEALTH, INC.

Inventor： Catalin BARBACIORU ,  Darya CHUDOVA ,  Aliaksandr ARTSIOMENKA ,  Daniel GAILE ,  Hao WANG

IPC: G16B30/10 ,  G16B20/20 ,  G16B20/10

Abstract: In implementations described herein, information derived from a sample that is derived from off-target sequences can be used to determine estimates for the copy number of tumor cells and/or the tumor fraction of a sample. Additionally, information derived from the presence of germline SNPs can be used to determine estimates for at least one of the copy number of tumor cells or the tumor fraction of a sample.