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    Flexible expandable electrode and method of intraluminal delivery of pulsed power
    1.
    发明授权
    Flexible expandable electrode and method of intraluminal delivery of pulsed power 有权

    公开(公告)号：US10314649B2

    公开(公告)日：2019-06-11

    申请号：US13565307

    申请日：2012-08-02

    申请人： Gregory J. Bakos ,  David N. Plescia ,  Gary L. Long ,  Peter K. Shires

    发明人： Gregory J. Bakos ,  David N. Plescia ,  Gary L. Long ,  Peter K. Shires

    IPC分类号： A61B18/18 ,  A61B18/14 ,  A61B17/00 ,  A61B18/00

    摘要： A surgical instrument, such as an electrical ablation device, includes an elongate member having therealong disposed a first electrode extending along an axis. A first expandable portion extends along the axis and defines a first perimeter of the first electrode and has an associated first diameter with respect to the axis. The first expandable portion includes a first framework selectively expandable to transition the first expandable portion from a contracted state to an expanded state. The first framework is selectively contractible to transition the first expandable portion from the expanded state to the contracted state. When the first framework is expanded, the first diameter is expanded and the first expandable portion is transitioned from the contracted state to the expanded state. When the first framework is contracted, the first diameter is contracted and the first expandable portion is transitioned from the expanded state to the contracted state.

    Needle probe guide
    5.
    发明授权
    Needle probe guide 有权
    针探针指南

    公开(公告)号：US09545290B2

    公开(公告)日：2017-01-17

    申请号：US13561945

    申请日：2012-07-30

    申请人： Karalyn R. Tellio ,  Mark S. Zeiner ,  David N. Plescia ,  Gary L. Long ,  Peter K. Shires

    发明人： Karalyn R. Tellio ,  Mark S. Zeiner ,  David N. Plescia ,  Gary L. Long ,  Peter K. Shires

    IPC分类号： A61B90/11 ,  A61B18/00 ,  A61B18/14

    CPC分类号： A61B90/11 ,  A61B18/1206 ,  A61B18/14 ,  A61B90/06 ,  A61B2017/00154 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00922 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2090/064

    摘要： A device for guiding electrodes relative to a tissue treatment region. The device can comprise a body have a plurality of passages therethrough. Each passage can axially restrain an electrode positioned therein. When each electrode is axially restrained in a passage, the distal ends of the electrodes can be spaced a predetermined distance apart. Further, the electrodes can be held in a parallel or substantially parallel alignment when axially retained in the passages. The predetermined distance between the electrodes can correspond to a treatment distance in a tissue treatment region and the distal ends of the electrodes can be operably structured to conduct current therebetween when at least one of electrodes is energized by an energy source.

    摘要翻译： 用于相对于组织处理区域引导电极的装置。 该装置可以包括具有穿过其中的多个通道的主体。 每个通道可以轴向限制位于其中的电极。 当每个电极轴向地限制在通道中时，电极的远端可以间隔开预定距离。 此外，当轴向保持在通道中时，电极可以保持平行或基本上平行的对准。 电极之间的预定距离可以对应于组织治疗区域中的治疗距离，并且当电极中的至少一个被能量源激励时，电极的远端可以可操作地构造成在其间传导电流。

    NEEDLE PROBE GUIDE
    6.
    发明申请
    NEEDLE PROBE GUIDE 有权
    针头探针指南

    公开(公告)号：US20140031813A1

    公开(公告)日：2014-01-30

    申请号：US13561945

    申请日：2012-07-30

    申请人： Karalyn R. Tellio ,  Mark S. Zeiner ,  David N. Plescia ,  Gary L. Long ,  Peter K. Shires

    发明人： Karalyn R. Tellio ,  Mark S. Zeiner ,  David N. Plescia ,  Gary L. Long ,  Peter K. Shires

    IPC分类号： A61B18/14

    CPC分类号： A61B90/11 ,  A61B18/1206 ,  A61B18/14 ,  A61B90/06 ,  A61B2017/00154 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00922 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2090/064

    摘要： A device for guiding electrodes relative to a tissue treatment region. The device can comprise a body have a plurality of passages therethrough. Each passage can axially restrain an electrode positioned therein. When each electrode is axially restrained in a passage, the distal ends of the electrodes can be spaced a predetermined distance apart. Further, the electrodes can be held in a parallel or substantially parallel alignment when axially retained in the passages. The predetermined distance between the electrodes can correspond to a treatment distance in a tissue treatment region and the distal ends of the electrodes can be operably structured to conduct current therebetween when at least one of electrodes is energized by an energy source.

    摘要翻译： 用于相对于组织处理区域引导电极的装置。 该装置可以包括具有穿过其中的多个通道的主体。 每个通道可以轴向限制位于其中的电极。 当每个电极轴向地限制在通道中时，电极的远端可以间隔开预定距离。 此外，当轴向保持在通道中时，电极可以保持平行或基本上平行的对准。 电极之间的预定距离可以对应于组织治疗区域中的治疗距离，并且当电极中的至少一个被能量源激励时，电极的远端可以可操作地构造成在其间传导电流。

    Electrical ablation devices and methods
    8.
    发明授权
    Electrical ablation devices and methods 有权
    电气消融装置及方法

    公开(公告)号：US09314620B2

    公开(公告)日：2016-04-19

    申请号：US13036908

    申请日：2011-02-28

    申请人： Gary L. Long ,  David N. Plescia ,  Gregory J. Bakos

    发明人： Gary L. Long ,  David N. Plescia ,  Gregory J. Bakos

    IPC分类号： A61B18/18 ,  A61N1/32 ,  A61B18/12 ,  A61B18/14 ,  A61B18/00 ,  A61B19/00

    CPC分类号： A61N1/327 ,  A61B18/1206 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00708 ,  A61B2018/00791 ,  A61B2090/064

    摘要： An electrical ablation device may generally comprise first and second electrodes coupled to an energy source operative to generate and deliver a first sequence of electrical pulses and a second sequence of electrical pulses to tissue having a necrotic threshold, wherein the first sequence of electrical pulses delivers a first energy dose that is less than the necrotic threshold to induce thermal heating in the tissue and the second sequence of electrical pulses delivers a second energy dose equal to or greater than the necrotic threshold to induce cell necrosis in the tissue by irreversible electroporation. The first sequence of electrical pulses may each be independently characterized by a first amplitude, a first pulse width, and a first frequency. The second sequence of electrical pulses may be characterized by a second amplitude, a second pulse width, and a second frequency.

    摘要翻译： 电消融装置通常可以包括耦合到能量源的第一和第二电极，其能够产生并递送电脉冲的第一序列和第二电脉冲序列到具有坏死阈值的组织，其中电脉冲的第一序列递送 第一能量剂量小于坏死阈值以诱导组织中的热加热，第二电脉冲序列传递等于或大于坏死阈值的第二能量剂量，以通过不可逆电穿孔诱导组织中的细胞坏死。 电脉冲的第一序列可以各自独立地以第一幅度，第一脉冲宽度和第一频率为特征。 电脉冲的第二序列可以由第二幅度，第二脉冲宽度和第二频率表征。

    ELECTRICAL ABLATION DEVICES AND METHODS
    10.
    发明申请
    ELECTRICAL ABLATION DEVICES AND METHODS 有权
    电气设备和方法

    公开(公告)号：US20120220998A1

    公开(公告)日：2012-08-30

    申请号：US13036908

    申请日：2011-02-28

    申请人： Gary L. Long ,  David N. Plescia ,  Gregory J. Bakos

    发明人： Gary L. Long ,  David N. Plescia ,  Gregory J. Bakos

    IPC分类号： A61B18/14

    CPC分类号： A61N1/327 ,  A61B18/1206 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00708 ,  A61B2018/00791 ,  A61B2090/064

    摘要： An electrical ablation device may generally comprise first and second electrodes coupled to an energy source operative to generate and deliver a first sequence of electrical pulses and a second sequence of electrical pulses to tissue having a necrotic threshold, wherein the first sequence of electrical pulses delivers a first energy dose that is less than the necrotic threshold to induce thermal heating in the tissue and the second sequence of electrical pulses delivers a second energy dose equal to or greater than the necrotic threshold to induce cell necrosis in the tissue by irreversible electroporation. The first sequence of electrical pulses may each be independently characterized by a first amplitude, a first pulse width, and a first frequency. The second sequence of electrical pulses may be characterized by a second amplitude, a second pulse width, and a second frequency.

    摘要翻译： 电消融装置通常可以包括耦合到能量源的第一和第二电极，其能够产生并递送电脉冲的第一序列和第二电脉冲序列到具有坏死阈值的组织，其中电脉冲的第一序列递送 第一能量剂量小于坏死阈值以诱导组织中的热加热，第二电脉冲序列传递等于或大于坏死阈值的第二能量剂量，以通过不可逆电穿孔诱导组织中的细胞坏死。 电脉冲的第一序列可以各自独立地以第一幅度，第一脉冲宽度和第一频率为特征。 电脉冲的第二序列可以由第二幅度，第二脉冲宽度和第二频率表征。