公开(公告)号：US20220267340A1

公开(公告)日：2022-08-25

申请号：US17740131

申请日：2022-05-09

Applicant: Genentech, Inc.

Inventor： Chen MAO ,  Dawen KOU ,  Po-Chang CHIANG

IPC: C07D487/04 ,  A61K9/14 ,  A61K9/20 ,  A61K31/4985 ,  A61K9/10 ,  C07C309/04

Abstract: The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound (S)-2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton's tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.

公开(公告)号：US20200299301A1

公开(公告)日：2020-09-24

申请号：US16889308

申请日：2020-06-01

Applicant: Genentech, Inc.

Inventor： Chen MAO ,  Dawen KOU ,  Po-Chang CHIANG

IPC: C07D487/04 ,  A61K9/14 ,  A61K9/20 ,  A61K31/4985 ,  C07C309/04

Abstract: The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound (S)-2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton's tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.

公开(公告)号：US20250109136A1

公开(公告)日：2025-04-03

申请号：US18793023

申请日：2024-08-02

Applicant: Genentech, Inc.

Inventor： Chen MAO ,  Dawen KOU ,  Po-Chang CHIANG

IPC: C07D487/04 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K31/4985 ,  C07C309/04

Abstract: The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound(S)-2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino) -6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton's tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.

公开(公告)号：US20230339957A1

公开(公告)日：2023-10-26

申请号：US18334515

申请日：2023-06-14

Applicant: Genentech, Inc.

Inventor： Chen MAO ,  Dawen KOU ,  Po-Chang CHIANG

IPC: A61K9/14 ,  C07C309/04 ,  A61K31/4985 ,  C07D487/04 ,  A61K9/20 ,  A61K9/10

CPC classification number: C07D487/04 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2013 ,  A61K31/4985 ,  C07C309/04 ,  C07B2200/13

Abstract: The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound (S)-2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro- [3,4′-bipyridin]-2′-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton’s tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.