公开(公告)号：US20230174596A1

公开(公告)日：2023-06-08

申请号：US17843595

申请日：2022-06-17

Applicant: Genentech, Inc.

Inventor： Rami HANNOUSH ,  Harini KALUARACHCHI ,  Aaron NILE ,  Cameron NOLAND ,  Yingnan ZHANG ,  Lijuan ZHOU ,  Xinxin GAO

IPC: C07K14/415 ,  A61K38/00 ,  C07K14/81 ,  C07K14/47 ,  A61K9/50 ,  A61K9/00 ,  A61K38/16 ,  A61K47/34 ,  C07K14/00

CPC classification number: C07K14/415 ,  A61K38/00 ,  C07K14/811 ,  C07K14/4702 ,  A61K9/5031 ,  A61K9/0051 ,  A61K38/168 ,  A61K47/34 ,  C07K14/001 ,  C07K2319/70

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US20240247034A1

公开(公告)日：2024-07-25

申请号：US18497741

申请日：2023-10-30

Applicant: Genentech, Inc.

Inventor： Rami HANNOUSH ,  Harini KALUARACHCHI ,  Aaron NILE ,  Cameron NOLAND ,  Yingnan ZHANG ,  Lijuan ZHOU ,  Xinxin GAO

IPC: C07K14/415 ,  A61K9/00 ,  A61K9/50 ,  A61K38/00 ,  A61K38/16 ,  A61K47/34 ,  C07K14/00 ,  C07K14/47 ,  C07K14/81

CPC classification number: C07K14/415 ,  A61K9/0051 ,  A61K9/5031 ,  A61K38/00 ,  A61K38/168 ,  A61K47/34 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/811 ,  C07K2319/70

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US20200325187A1

公开(公告)日：2020-10-15

申请号：US16915387

申请日：2020-06-29

Applicant: Genentech, Inc.

Inventor： Rami HANNOUSH ,  Harini KALUARACHCHI ,  Aaron NILE ,  Cameron NOLAND ,  Yingnan ZHANG ,  Lijuan ZHOU ,  Xinxin GAO

IPC: C07K14/415 ,  A61K38/00 ,  C07K14/81 ,  C07K14/47 ,  A61K9/50 ,  A61K9/00 ,  A61K38/16 ,  A61K47/34 ,  C07K14/00

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, Including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US20180291069A1

公开(公告)日：2018-10-11

申请号：US15944700

申请日：2018-04-03

Applicant: Genentech, Inc.

Inventor： Rami HANNOUSH ,  Harini KALUARACHCHI ,  Aaron NILE ,  Cameron NOLAND ,  Yingnan ZHANG ,  Lijuan ZHOU ,  Xinxin GAO

IPC: C07K14/415 ,  A61K9/50 ,  C07K14/00 ,  A61K9/00 ,  C07K14/81 ,  A61K38/00 ,  A61K47/34 ,  A61K38/16 ,  C07K14/47

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US20170129927A1

公开(公告)日：2017-05-11

申请号：US15267087

申请日：2016-09-15

Applicant: Genentech, Inc.

Inventor： Rami HANNOUSH ,  Harini KALUARACHCHI ,  Aaron NILE ,  Cameron NOLAND ,  Yingnan ZHANG ,  Lijuan ZHOU ,  Xinxin GAO

IPC: C07K14/415 ,  A61K47/34 ,  A61K9/00 ,  C07K14/00 ,  A61K38/16

CPC classification number: C07K14/415 ,  A61K9/0051 ,  A61K9/5031 ,  A61K38/00 ,  A61K38/168 ,  A61K47/34 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/811 ,  C07K2319/70

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US20240059755A1

公开(公告)日：2024-02-22

申请号：US18078556

申请日：2022-12-09

Applicant: Genentech, Inc.

Inventor： Whitney BINDER ,  Craig D. BLANCHETTE ,  Martine A. DARWISH ,  Rami HANNOUSH ,  Xinxin GAO

IPC: C07K14/775 ,  C07K16/28

CPC classification number: C07K14/775 ,  C07K16/2875 ,  C07K2317/55 ,  C07K2319/30 ,  C07K2319/31

Abstract: The present invention generally relates to nanolipoprotein particle conjugates comprising at least one polypeptide and nanolipoprotein particle conjugates comprising at least one short peptide between 20-60 amino acids in length. Also provided are related compositions and systems, and methods of preparing and using same. In particular, nanolipoprotein particle (NLP) conjugates with antigen-binding fragments (Fabs) are provided, where the NLP comprises a bilayer of membrane-forming lipids encircled by scaffold proteins, and the Fabs are conjugated to one or both bilayer surfaces. In some embodiments, the (NLP) conjugates further comprise a short peptide 20-60 amino acids in length. The conjugates, and related compositions and systems, generally show good stability and manufacturability, retain antigen-binding activity, and can enhance antigen-binding potency, providing versatile platforms for delivery of Fab and Fab-based therapeutics and diagnostics, as well as providing stable platforms for delivering other therapeutic and/or diagnostic agents.

公开(公告)号：US20200231636A1

公开(公告)日：2020-07-23

申请号：US16574917

申请日：2019-09-18

Applicant: Genentech, Inc.

Inventor： Rami HANNOUSH ,  Harini KALUARACHCHI ,  Aaron NILE ,  Cameron NOLAND ,  Yingnan ZHANG ,  Lijuan ZHOU ,  Xinxin GAO

IPC: C07K14/415 ,  C07K14/00 ,  A61K47/34 ,  A61K38/16 ,  A61K9/00 ,  A61K9/50 ,  C07K14/47 ,  C07K14/81 ,  A61K38/00

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.