公开(公告)号：US20210030888A1

公开(公告)日：2021-02-04

申请号：US16978539

申请日：2019-03-06

Applicant: Genmab A/S

Inventor： Reshma Abdulla RANGWALA ,  Esther Cornelia Wilhelmina BREIJ ,  David SATIJN ,  Sandra VERPLOEGEN ,  Jantine BAKEMA ,  Oyewale O. ABIDOYE ,  Leonardo Viana NICACIO ,  Andreas LINGNAU

IPC: A61K47/68 ,  C07K16/36 ,  A61K9/00 ,  A61P35/00

Abstract: The invention provides methods and compositions for treating cancer, such as colorectal cancer, non-small cell lung cancer, pancreatic cancer, head and neck cancer, bladder cancer, endometrial cancer, esophageal cancer and prostate cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., colorectal cancer, non-small cell lung cancer, pancreatic cancer, head and neck cancer, bladder cancer, endometrial cancer, esophageal cancer and prostate cancer).