公开(公告)号：US20230293680A1

公开(公告)日：2023-09-21

申请号：US18017241

申请日：2021-07-23

Applicant: Genmab B.V.

Inventor： Hilma VAN DER HORST ,  Tuna MUTIS ,  Kristin STRUMANE ,  Esther BREIJ ,  Marije OVERDIJK

IPC: A61K39/395 ,  A61K31/454 ,  A61K31/69 ,  A61P35/00

CPC classification number: A61K39/3955 ,  A61K31/454 ,  A61K31/69 ,  A61P35/00 ,  A61K2039/507

Abstract: The present invention relates to the treatment of multiple myeloma using a combination of two antibody molecules that bind to human DR5 antigen and an immunomodulatory imide dmg. The present invention further relates to treatment of relapsed and/or refectory multiple myeloma.