公开(公告)号：US20230084937A1

公开(公告)日：2023-03-16

申请号：US17883452

申请日：2022-08-08

Applicant: Gentium S.R.L.

Inventor： Massimo IACOBELLI

IPC: A61K31/711 ,  A61P1/16 ,  A61K9/00

Abstract: In various embodiments, the present disclosure teaches methods of treating patients diagnosed as having sinusoidal obstruction syndrome with defibrotide.

公开(公告)号：US20190328765A1

公开(公告)日：2019-10-31

申请号：US16398978

申请日：2019-04-30

Applicant: GENTIUM S.R.L.

Inventor： Massimo IACOBELLI

IPC: A61K31/711 ,  A61K9/00 ,  A61P1/16

Abstract: In various embodiments, the present disclosure teaches methods of treating patients diagnosed as having sinusoidal obstruction syndrome with defibrotide.

公开(公告)号：US20170080012A1

公开(公告)日：2017-03-23

申请号：US15366213

申请日：2016-12-01

Applicant: GENTIUM S.R.L.

Inventor： Massimo IACOBELLI

IPC: A61K31/711 ,  A61K9/08 ,  A61K9/00

CPC classification number: A61K31/711 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/7088 ,  C12N15/11 ,  C12N15/111

Abstract: Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD) in humans is disclosed, preferably in hematopoietic stem cell transplantation (HSCT), more preferably allogeneic hematopoietic stem cell transplantation. Graft versus Host Disease of the invention (GVHD) can be acute aGVHD and/or chronic cGVHD, preferably acute.

公开(公告)号：US20210052622A1

公开(公告)日：2021-02-25

申请号：US16942328

申请日：2020-07-29

Applicant: GENTIUM S.R.L.

Inventor： Massimo IACOBELLI

IPC: A61K31/711 ,  C12N15/11 ,  A61K31/7088 ,  A61K9/00 ,  A61K9/08

Abstract: Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD) in humans is disclosed, preferably in hematopoietic stem cell transplantation (HSCT), more preferably allogeneic hematopoietic stem cell transplantation. Graft versus Host Disease of the invention (GVHD) can be acute aGVHD and/or chronic cGVHD, preferably acute.

公开(公告)号：US20170304349A1

公开(公告)日：2017-10-26

申请号：US15645330

申请日：2017-07-10

Applicant: GENTIUM S.R.L.

Inventor： Massimo IACOBELLI

IPC: A61K31/711 ,  A61K31/7088 ,  A61K9/00 ,  A61K9/08 ,  C12N15/11

CPC classification number: A61K31/711 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/7088 ,  C12N15/11 ,  C12N15/111

Abstract: Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD) in humans is disclosed, preferably in hematopoietic stem cell transplantation (IISCT), more preferably allogeneic hernatopoietic stein cell transplantation. Graft versus Host Disease oldie invention (GVHD) can be acute aGVHD and/or chronic cOVHD, preferably acute.