公开(公告)号：US06288093B1

公开(公告)日：2001-09-11

申请号：US09697151

申请日：2000-10-27

申请人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

发明人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

IPC分类号： A61K31429

CPC分类号： C07D277/60 ,  C07D513/04

摘要： The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example as anorectics and in the treatment or prophylaxis of type II diabetes.

摘要翻译： 本发明涉及多环噻唑烷-2-亚基胺及其生理上耐受的盐和生理功能衍生物。式I的多环噻唑烷-2-亚基胺，其中基团具有所述含义，以及它们的生理学耐受的盐和方法 描述了它们的准备。 这些化合物是适合的，例如作为抗精神病药和治疗或预防II型糖尿病。

公开(公告)号：US06207689B1

公开(公告)日：2001-03-27

申请号：US09500464

申请日：2000-02-09

申请人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

发明人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

IPC分类号： A61K31428

CPC分类号： C07D277/60 ,  C07D513/04

摘要： The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example as anorectics and in the treatment or prophylaxis of type II diabetes.

公开(公告)号：US06187801B1

公开(公告)日：2001-02-13

申请号：US09501210

申请日：2000-02-10

申请人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

发明人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

IPC分类号： A61K31428

CPC分类号： C07D277/60 ,  C07D277/84 ,  C07D417/04 ,  C07D417/06

摘要： The invention relates to polycyclic thiazole systems and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.

摘要翻译： 本发明涉及多环噻唑体系及其生理上耐受的盐和生理功能衍生物。描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 所述化合物例如适合作为抗精神病药。

公开(公告)号：US06476059B1

公开(公告)日：2002-11-05

申请号：US09501209

申请日：2000-02-10

申请人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

发明人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

IPC分类号： A61P304

CPC分类号： C07D277/60 ,  C07D277/82 ,  C07D513/04 ,  Y10S514/909

摘要： The invention relates to the use of polycyclic 2-aminothiazole systems and their physiologically tolerated salts and physiologically functional derivatives for the treatment of obesity. The treatment involves administration of a compound of formula I, in which the radicals have the stated meanings, and of their physiologically tolerated salts and physiologically functional derivatives.

摘要翻译： 本发明涉及多环2-氨基噻唑体系及其生理上耐受的盐和生理功能衍生物用于治疗肥胖症的用途。治疗涉及给予式I化合物，其中基团具有所述含义，以及它们 生理上耐受的盐和生理功能衍生物。

公开(公告)号：US06288094B1

公开(公告)日：2001-09-11

申请号：US09774053

申请日：2001-01-31

申请人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

发明人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

IPC分类号： A61K31429

摘要： The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example as anorectics and in the treatment or prophylaxis of type II diabetes.

公开(公告)号：US06329407B1

公开(公告)日：2001-12-11

申请号：US09500463

申请日：2000-02-09

申请人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

发明人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

IPC分类号： A61K31425

CPC分类号： A61K31/428 ,  A61K31/425 ,  A61K2300/00

摘要： The invention relates to the use of polycyclic thiazole systems and their physiologically tolerated salts and physiologically functional derivatives for the treatment of obesity. The treatment involves administration of a compound of formula I, in which the radicals have the stated meanings, and of their physiologically tolerated salts and physiologically functional derivatives.

摘要翻译： 本发明涉及多环噻唑体系及其生理学耐受盐和生理功能衍生物用于治疗肥胖症的用途。治疗涉及给予式Ⅰ化合物，其中自由基具有所述含义及其生理耐受性 盐和生理功能衍生物。

公开(公告)号：US06251922B1

公开(公告)日：2001-06-26

申请号：US09501208

申请日：2000-02-10

申请人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

发明人： Gerhard Jähne ,  Karl Geisen ,  Hans-Jochen Lang ,  Martin Bickel

IPC分类号： A61K314439

CPC分类号： C07D277/60

摘要： The invention relates to polycyclic 2-aminothiazole systems and their physiologically tolerated salts and physiologically functional derivatives. The polycyclic 2-aminothiazole systems are according to formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.

摘要翻译： 本发明涉及多环2-氨基噻唑体系及其生理上耐受的盐和生理功能衍生物。 多环2-氨基噻唑系统是根据式I，其中基团具有所述含义，并且描述了它们的生理学耐受盐及其制备方法。 所述化合物例如适合作为抗精神病药。

公开(公告)号：US06358978B1

公开(公告)日：2002-03-19

申请号：US09599390

申请日：2000-06-22

申请人： Olaf Ritzeler ,  Hans Ulrich Stilz ,  Bernhard Neises ,  William Jerome Bock, Jr. ,  Armin Walser ,  Gary A. Flynn ,  Jörg Habermann ,  Gerhard Jähne

发明人： Olaf Ritzeler ,  Hans Ulrich Stilz ,  Bernhard Neises ,  William Jerome Bock, Jr. ,  Armin Walser ,  Gary A. Flynn ,  Jörg Habermann ,  Gerhard Jähne

IPC分类号： A61K31445

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D471/04

摘要： Compounds of formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF&kgr;B is involved.

摘要翻译： 式I化合物适用于生产用于预防和治疗疾病的药物，其中涉及NFκB活性增加。