公开(公告)号：US10392617B2

公开(公告)日：2019-08-27

申请号：US15109879

申请日：2015-01-06

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Hilla Giladi ,  Alina Simerzin ,  Yael Hantz ,  Sagit Arbel Alon ,  Eithan Galun

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7105 ,  A61K45/06 ,  A61K31/713 ,  A61K31/7088

Abstract: The present invention provides miR-122* as a functional microRNA molecule, compositions comprising the same and uses thereof for treatment of various conditions, such as, cancer. Further provided are methods for increasing the expression, stability and/or activity of p53 in a target cell or method for inducing cancer cell death, the methods comprising introducing into the cell a miR-122* polynucleotide molecule or a vector expressing or encoding the same.