公开(公告)号：US20240216328A1

公开(公告)日：2024-07-04

申请号：US18490008

申请日：2023-10-19

Applicant: HOWARD UNIVERSITY

Inventor： Simeon Kolawole ADESINA

IPC: A61K31/366 ,  A61K9/51 ,  A61K31/337 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20

CPC classification number: A61K31/366 ,  A61K9/5146 ,  A61K9/5184 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20 ,  A61K38/00

Abstract: Disclosed are bruceolides for the treatment of cancer, and oilier diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.