公开(公告)号：US20240358704A1

公开(公告)日：2024-10-31

申请号：US18627727

申请日：2024-04-05

申请人： Hoffmann-La Roche Inc.

发明人： Nicole HELLBACH ,  Heidemarie KLETZL ,  Friedrich METZGER ,  Renata SICILIANI SCALCO

IPC分类号： A61K31/519 ,  A61K9/00 ,  A61K9/08 ,  A61K39/00 ,  A61K39/395 ,  A61P21/00

CPC分类号： A61K31/519 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K39/3955 ,  A61P21/00 ,  A61K2039/545

摘要： The invention relates to 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one, also known as risdiplam, for use in the treatment of spinal muscular atrophy (SMA) with GYM329, its pharmaceutical composition to be used in the treatment of SMA, its methods of treatment thereof.