公开(公告)号：US20210055304A1

公开(公告)日：2021-02-25

申请号：US16945730

申请日：2020-07-31

申请人： Hoffmann-La Roche Inc.

发明人： Kay-Gunnar STUBENRAUCH ,  Uwe WESSELS

IPC分类号： G01N33/68 ,  G01N33/543

摘要： Herein is reported a method for the detection of free antigen of a multispecific antibody in a sample, whereby the antigen to be detected can be specifically bound by a first binding site of the multispecific antibody, comprising the step of incubating a sample comprising free antigen and multispecific antibody with an anti-idiotypic antibody, which specifically binds to a second binding specificity of the bispecific antibody, which is different from the first binding specificity, whereby the anti-idiotypic antibody is bound to a solid phase.

公开(公告)号：US20180328942A1

公开(公告)日：2018-11-15

申请号：US15923773

申请日：2018-03-16

申请人： Hoffmann-La Roche Inc.

发明人： Kay-Gunnar STUBENRAUCH ,  Uwe WESSELS

IPC分类号： G01N33/68 ,  G01N33/543

摘要： Herein is reported a method for the detection of free antigen of a multispecific antibody in a sample, whereby the antigen to be detected can be specifically bound by a first binding site of the multispecific antibody, comprising the step of incubating a sample comprising free antigen and multispecific antibody with an anti-idiotypic antibody, which specifically binds to a second binding specificity of the bispecific antibody, which is different from the first binding specificity, whereby the anti-idiotypic antibody is bound to a solid phase.