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    CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME
    3.
    发明申请
    CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME 有权
    生产L-阿魏酸的罗丹明葡萄球菌及其制备方法

    公开(公告)号：US20100041109A1

    公开(公告)日：2010-02-18

    申请号：US12522280

    申请日：2008-01-11

    申请人： Hye Won Kim ,  Hyejin Choi ,  Ji-Hye Lee ,  Soo Youn Hwang

    发明人： Hye Won Kim ,  Hyejin Choi ,  Ji-Hye Lee ,  Soo Youn Hwang

    IPC分类号： C12P13/10 ,  C12N1/21

    CPC分类号： C12P13/10

    摘要： The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argD2 gene (Ncgl2355) that is a putative gene of acetylornithine aminotransferase involved in arginine biosynthesis of Corynebacterium glutamicum, a polypeptide encoded by the polynucleotide, a recombinant vector comprising the polynucleotide, a transformant capable of producing L-arginine in a high yield, which is prepared by introducing the recombinant vector into an L-arginine producing host microorganism to overexpress the argD2 gene, and a method for producing L-arginine by culturing the transformant. The transformant of the present invention overexpresses the argD2 gene to produce L-arginine in a high yield, thereby being used in medicinal and pharmaceutical industries.

    摘要翻译： 本发明涉及L-精氨酸生产突变菌株及其制造方法。 特别地，本发明涉及包含argD2基因（Ncgl2355）的多核苷酸，其是参与谷氨酸棒杆菌的精氨酸生物合成的乙酰鸟氨酸氨基转移酶的推定基因，由该多核苷酸编码的多肽，包含多核苷酸的重组载体，能够转化的转化体 通过将重组载体导入产生L-精氨酸的宿主微生物以过表达argD2基因而制备L-精氨酸，以及通过培养转化体来生产L-精氨酸的方法。 本发明的转化体以高产率过表达argD2基因产生L-精氨酸，从而用于医药和制药工业。

    Method for producing L-arginine using Corynebacterium glutamicum
    4.
    发明授权
    Method for producing L-arginine using Corynebacterium glutamicum 有权
    使用谷氨酸棒杆菌生产L-精氨酸的方法

    公开(公告)号：US08034602B2

    公开(公告)日：2011-10-11

    申请号：US12309048

    申请日：2007-07-12

    申请人： Young Hoon Park ,  Hye Won Kim ,  Ji-Hye Lee ,  Soo-Youn Hwang

    发明人： Young Hoon Park ,  Hye Won Kim ,  Ji-Hye Lee ,  Soo-Youn Hwang

    IPC分类号： C12N1/20 ,  C12P13/10

    CPC分类号： C12R1/15 ,  C12P13/10

    摘要： Disclosed herein are a microorganism producing L-arginine and a method of producing L-arginine using the same. The microorganism is a mutant strain of the genus Corynebacterium, Corynebacterium glutamicum CJR0500. The method for L-arginine production comprises activating the mutant strain C. glutamicum CJR0500 in a fermentation medium at 30° C. for 16 hours and then culturing the activated mutant strain for 72 hours with shaking.

    摘要翻译： 本文公开了生产L-精氨酸的微生物和使用其的L-精氨酸的生产方法。 微生物是棒状杆菌属（Corynebacterium），谷氨酸棒杆菌（Corynebacterium glutamicum）CJR0500的突变菌株。 L-精氨酸生产方法包括在30℃的发酵培养基中活化突变菌株C.谷氨酸棒杆菌CJR0500 16小时，然后摇动培养活化的突变菌株72小时。

    Corynebacterium glutamicum variety producing L-arginine and method for fabricating the same
    5.
    发明授权
    Corynebacterium glutamicum variety producing L-arginine and method for fabricating the same 有权
    产生L-精氨酸的谷氨酸棒杆菌品种及其制造方法

    公开(公告)号：US08048648B2

    公开(公告)日：2011-11-01

    申请号：US12522280

    申请日：2008-01-11

    申请人： Hye Won Kim ,  Hyejin Choi ,  Ji-Hye Lee ,  Soo Youn Hwang

    发明人： Hye Won Kim ,  Hyejin Choi ,  Ji-Hye Lee ,  Soo Youn Hwang

    IPC分类号： C12P13/10 ,  C12N1/20

    CPC分类号： C12P13/10

    摘要： The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argD2 gene (Ncgl2355) that is a putative gene of acetylornithine aminotransferase involved in arginine biosynthesis of Corynebacterium glutamicum, a polypeptide encoded by the polynucleotide, a recombinant vector comprising the polynucleotide, a transformant capable of producing L-arginine in a high yield, which is prepared by introducing the recombinant vector into an L-arginine producing host microorganism to overexpress the argD2 gene, and a method for producing L-arginine by culturing the transformant. The transformant of the present invention overexpresses the argD2 gene to produce L-arginine in a high yield, thereby being used in medicinal and pharmaceutical industries.

    摘要翻译： 本发明涉及L-精氨酸生产突变菌株及其制造方法。 特别地，本发明涉及包含argD2基因（Ncgl2355）的多核苷酸，其是参与谷氨酸棒杆菌的精氨酸生物合成的乙酰鸟氨酸氨基转移酶的推定基因，由该多核苷酸编码的多肽，包含多核苷酸的重组载体，能够转化的转化体 通过将重组载体导入产生L-精氨酸的宿主微生物以过表达argD2基因而制备L-精氨酸，以及通过培养转化体来生产L-精氨酸的方法。 本发明的转化体以高产率过表达argD2基因产生L-精氨酸，从而用于医药和制药工业。

    Method for Producing L-Arginine Using Corynebacterium Glutamicum
    6.
    发明申请
    Method for Producing L-Arginine Using Corynebacterium Glutamicum 有权
    使用谷氨酸棒杆菌生产L-精氨酸的方法

    公开(公告)号：US20090311757A1

    公开(公告)日：2009-12-17

    申请号：US12309048

    申请日：2007-07-12

    申请人： Young Hoon Park ,  Hye Won Kim ,  Ji-Hye Lee ,  Soo-Youn Hwang

    发明人： Young Hoon Park ,  Hye Won Kim ,  Ji-Hye Lee ,  Soo-Youn Hwang

    IPC分类号： C12P13/10 ,  C12N1/21

    CPC分类号： C12R1/15 ,  C12P13/10

    摘要： Disclosed herein are a microorganism producing L-arginine and a method of producing L-arginine using the same. The microorganism is a mutant strain of the genus Corynebacterium, Corynebacterium glutamicum CJR0500. The method for L-arginine production comprises activating the mutant strain C. glutamicum CJR0500 in a fermentation medium at 30° C. for 16 hours and then culturing the activated mutant strain for 72 hours with shaking.

    摘要翻译： 本文公开了生产L-精氨酸的微生物和使用其的L-精氨酸的生产方法。 微生物是棒状杆菌属（Corynebacterium），谷氨酸棒杆菌（Corynebacterium glutamicum）CJR0500的突变菌株。 L-精氨酸生产方法包括在30℃的发酵培养基中活化突变菌株C.谷氨酸棒杆菌CJR0500 16小时，然后摇动培养活化的突变菌株72小时。