公开(公告)号：US10709793B2

公开(公告)日：2020-07-14

申请号：US16179876

申请日：2018-11-02

申请人： INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS

发明人： Yong-Hee Kim ,  Tae-Hwan Kim ,  Chul-Su Yang ,  Yoonsung Song ,  Jee-Young Chung ,  Sungsin Jo ,  So Mi Kim ,  Qurrat Ui Ain ,  Ye-Ram Kim

IPC分类号： C07H21/04 ,  A61K47/62 ,  C12N15/113 ,  A61K31/7088 ,  A61P37/06 ,  A61P19/02 ,  A61K47/64

摘要： Disclosed is a gene/carrier complex for preventing or treating inflammatory diseases, including tumor necrosis factor-α converting enzyme (TNF-α converting enzyme, TACE) shRNA and a nonviral gene carrier, wherein the nonviral gene carrier includes an acetate of disulfide-linked poly(oligo-arginine) or a TFA salt of poly(oligo-aspartic acid)poly(oligo-arginine).