公开(公告)号：US11083785B2

公开(公告)日：2021-08-10

申请号：US15776452

申请日：2016-11-17

Applicant: INNATE PHARMA

Inventor： Stephanie Cornen ,  Laurent Gauthier ,  Benjamin Rossi ,  Nicolai Wagtmann

IPC: C07K14/705 ,  A61K39/00 ,  C07K16/28 ,  A61P35/00

Abstract: This disclosure relates to agents that bind and neutralize the inhibitory activity of Siglec-10 in lymphocytes, notably by inhibiting the binding of Siglec-10 to its sialic acid ligands on target cells, notably tumor cells. Such agents can be used for the treatment of cancers.

公开(公告)号：US11078274B2

公开(公告)日：2021-08-03

申请号：US16082959

申请日：2017-03-07

Applicant: INNATE PHARMA

Inventor： Stephanie Cornen ,  Benjamin Rossi ,  Nicolai Wagtmann

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C12N5/12 ,  G01N33/574

Abstract: This invention relates to agents that bind human Siglecs having inhibitory activity in immune cells, and that neutralize the inhibitory activity of such Siglec. Such agents can be used for the treatment of cancers or infectious disease.