公开(公告)号：US20160046713A1

公开(公告)日：2016-02-18

申请号：US14924786

申请日：2015-10-28

Applicant: INNATE PHARMA

Inventor： NICOLAS ANFOSSI ,  LAURENT GAUTHIER ,  YANNIS MOREL ,  ALESSANDRO MORETTA ,  SILVIA PAROLINI ,  BENJAMIN ROSSI

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732

Abstract: The present invention provides antigen-binding proteins capable of binding to KIR3D polypeptides. The antibodies have increased activity in the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sézary Syndrome.

Abstract translation: 本发明提供能够结合KIR3D多肽的抗原结合蛋白。 抗体在治疗特征为表达KIR3DL2的细胞，特别是CD4 + T细胞，包括恶性肿瘤例如真菌病真菌和Sézary综合征的疾病中具有增加的活性。

公开(公告)号：US20250002601A1

公开(公告)日：2025-01-02

申请号：US18568806

申请日：2022-06-08

Applicant: INNATE PHARMA

Inventor： LAURENT GAUTHIER ,  YANNIS MOREL ,  OLIVIER DEMARIA ,  BENJAMIN ROSSI

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K14/55

Abstract: The present invention relates to multispecific protein that binds to human NKp46, human CD20, human CD122, and optionally human CD16A. The protein according to the invention have utility in the treatment of disease, such as cancer.

公开(公告)号：US20140234323A1

公开(公告)日：2014-08-21

申请号：US14268242

申请日：2014-05-02

Applicant: Innate Pharma

Inventor： KARINE CHEMIN ,  LAURENT GAUTHIER ,  YANNIS MOREL ,  CARINE PATUREL ,  AGNES TISSERANT

IPC: C07K16/30 ,  G01N33/574

CPC classification number: C07K16/30 ,  C07K16/2896 ,  G01N33/57415 ,  G01N33/57492

Abstract: The present invention relates to antibodies, antibody fragments, and derivatives thereof that specifically bind to TLR3 cell receptors present on the surface of cells. The invention also relates to hybridomas producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to detect TLR3 levels on the surface of cells, and the use of such antibodies and compositions for diagnostic or therapeutic purposes in subjects.

Abstract translation: 本发明涉及特异性结合存在于细胞表面上的TLR3细胞受体的抗体，抗体片段及其衍生物。 本发明还涉及产生这种抗体的杂交瘤; 制备此类抗体的方法; 抗体的片段，变体和衍生物; 包含它们的药物组合物; 使用抗体检测细胞表面上的TLR3水平的方法，以及在受试者中用于诊断或治疗目的的此类抗体和组合物的用途。