公开(公告)号：US12194042B2

公开(公告)日：2025-01-14

申请号：US17287478

申请日：2019-10-21

Applicant: INTRA-CELLULAR THERAPIES, INC.

Inventor： Robert E. Davis ,  Kimberly E. Vanover

IPC: A61K31/519 ,  A61P25/16 ,  C07D487/14

Abstract: The disclosure provides methods, treatments and materials for treating diseases or disorders associated with the dopamine D1 receptor intracellular pathway. In particular, the present disclosure provides for methods of treating such diseases and disorders in combination with a dopamine replacement therapy.

公开(公告)号：US20210369715A1

公开(公告)日：2021-12-02

申请号：US17336798

申请日：2021-06-02

Applicant: INTRA-CELLULAR THERAPIES, INC.

Inventor： Peng Li ,  Robert E. Davis

IPC: A61K31/519 ,  A61K45/06

Abstract: The disclosure provides the administration of inhibitors of phosphodiesterase 1 (PDE1) for the treatment and prophylaxis of diseases or disorders characterized by inflammation, including methods of treatment and pharmaceutical compositions for use therein.