公开(公告)号：US20240020529A1

公开(公告)日：2024-01-18

申请号：US18034149

申请日：2021-10-27

Applicant: ISP INVESTMENTS LLC

Inventor： Yunxia BI ,  Thomas DURIG ,  Solomon Howard JACOBSON

IPC: G06N3/08

CPC classification number: G06N3/08

Abstract: Present invention is directed to an artificial intelligence-based method and a system, that uses both experimental results data and molecular simulation to predict properties of amorphous solid dispersions such as glass transition temperature, dissolution profile, and/or physical stability. The method and system of the present invention enable rational design of amorphous solid dispersions for poorly water-soluble drugs and significantly reduce the time and resource required for amorphous solid dispersions formulation development.