公开(公告)号：US20210061796A1

公开(公告)日：2021-03-04

申请号：US16644581

申请日：2018-09-06

申请人： Immunic AG

发明人： Jakob FELDING ,  Hella KOHLHOF ,  Manfred GROPPEL ,  Rolf Andreas MUHLER ,  Daniel VITT ,  Carine CHEVRIER ,  Mirko ZAJA ,  Stefan TASLER

IPC分类号： C07D413/04 ,  C07D417/14

摘要： The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.