公开(公告)号：US20180067050A1

公开(公告)日：2018-03-08

申请号：US15686320

申请日：2017-08-25

Applicant: Industrial Technology Research Institute

Inventor： Hung-Chun CHEN ,  Ming-Chia LI ,  Chang-Sheng CHU ,  Yu-Tang LI ,  Chung-Fan CHIOU

IPC: G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6428 ,  C12Q1/6869 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607 ,  G01N15/1459 ,  G01N21/645 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6441

Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light detector comprising at least two optical sensors capable of determining the intensity of the light; and a computer processing output signal generated by the optical sensors and comparing a result of the processing with a known result corresponding to a known type to determine whether the object belongs to the known type.

公开(公告)号：US20180018425A1

公开(公告)日：2018-01-18

申请号：US15659585

申请日：2017-07-25

Applicant: Industrial Technology Research Institute

Inventor： Chao-Chi PAN ,  Jenn-Yeh FANN ,  Chung-Fan CHIOU ,  Hung-Chi CHIEN ,  Hui-Ling CHEN

IPC: G06F19/22 ,  C12Q1/68

Abstract: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.