公开(公告)号：US20070149523A1

公开(公告)日：2007-06-28

申请号：US11559662

申请日：2006-11-14

申请人： Jan Ehlert ,  Thomas Herz ,  Rolf Krauss ,  Micheal Kubbutat ,  Martin Lang ,  Stefano Pegoraro ,  Christoph Schachtele ,  Frank Totzke ,  Ute Zirrgiebel

发明人： Jan Ehlert ,  Thomas Herz ,  Rolf Krauss ,  Micheal Kubbutat ,  Martin Lang ,  Stefano Pegoraro ,  Christoph Schachtele ,  Frank Totzke ,  Ute Zirrgiebel

IPC分类号： A61K31/5377 ,  A61K31/53 ,  A61K31/52 ,  A61K31/519 ,  A61K31/506 ,  A61K31/4745 ,  A61K31/4439 ,  C07D473/02 ,  C07D487/02 ,  C07D417/02

CPC分类号： C07D417/12

摘要： Compounds of formula (I) and salts and physiologically functional derivatives thereof, wherein R2 is attached at the 4- or 5-position of the thiazole ring and is hydrogen, alkyl, halogen, cyano, alkoxy, haloalkoxy, or alkylamino; X independently represents a divalent linkage group selected from S, O, NR4, SO, or SO2; R4 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, or heterocyclyl; R1 is attached at the 4- or 5-position of the thiazole ring and independently represents a group of formula (II):  wherein the dotted line represents a single or double bond; * indicates the point of attachment to the thiazole ring; and n is 1, 2, or 3. Also disclosed are pharmaceutical compositions comprising the above compounds and method of treatments for cancer and other diseases.

摘要翻译： 式（I）化合物及其盐和生理功能衍生物，其中R 2连接在噻唑环的4-或5-位，并且是氢，烷基，卤素，氰基，烷氧基， 卤代烷氧基或烷基氨基; X独立地表示选自S，O，NR 4，SO或SO 2的二价键合基​​团。 R 4是氢，烷基，环烷基，环烷基烷基或杂环基; R 1连接在噻唑环的4-或5-位，独立地表示式（II）的基团：其中虚线表示单键或双键; *表示与噻唑环的连接点; 并且n为1,2或3.还公开了包含上述化合物的药物组合物和用于癌症和其它疾病的治疗方法。