公开(公告)号：US20110319375A1

公开(公告)日：2011-12-29

申请号：US13190330

申请日：2011-07-25

申请人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Durón ,  Michael Christopher Scaife ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Andrew M. Trammel ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Durón ,  Michael Christopher Scaife ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Andrew M. Trammel ,  Jeffrey P. Harris

IPC分类号： A61K31/573 ,  A61P27/16

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US20110319373A1

公开(公告)日：2011-12-29

申请号：US13190323

申请日：2011-07-25

申请人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

IPC分类号： A61K31/573 ,  A61P27/16

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US08846770B2

公开(公告)日：2014-09-30

申请号：US12486697

申请日：2009-06-17

申请人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Durón ,  Michael Christopher Scaife ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Andrew M. Trammel ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Durón ,  Michael Christopher Scaife ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Andrew M. Trammel ,  Jeffrey P. Harris

IPC分类号： A61K47/30 ,  A61K9/14 ,  A61K31/724

CPC分类号： A61K47/34 ,  A61K9/14 ,  A61K31/5377 ,  A61K31/5517 ,  A61K31/724

摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开的是用于治疗耳科疾病或病症的组合物和方法，所述耳科疾病或病症具有耳神经压力调节剂组合物和通过直接将这些组合物和制剂直接施用于或经由灌注到目标物中而局部施用于患有耳科疾病或病症的个体的制剂 耳结构。

公开(公告)号：US08680083B2

公开(公告)日：2014-03-25

申请号：US13190329

申请日：2011-07-25

申请人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

IPC分类号： A01N45/00 ,  A61K31/56 ,  A61K47/30 ,  C07J1/00 ,  A61K9/14

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开了用类固醇，NSAID和/或腺苷三磷酸酶（“ATPase”）调节剂治疗耳部疾病的组合物和方法。 在这些方法中，通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中，将甾体，NSAID和/或ATP酶组合物和制剂局部施用于患有耳科疾病的个体。

公开(公告)号：US08680082B2

公开(公告)日：2014-03-25

申请号：US13190323

申请日：2011-07-25

申请人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

IPC分类号： A01N45/00 ,  A61K31/56 ,  A61K47/30 ,  C07J1/00 ,  A61K9/14

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US20110319377A1

公开(公告)日：2011-12-29

申请号：US13190329

申请日：2011-07-25

申请人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Andrew M. Trammel ,  Sergio G. Durón ,  Fabrice Piu ,  Luis A. Dellamary ,  Qiang Ye ,  Carl Lebel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

IPC分类号： A61K31/573 ,  A61P27/16 ,  A61P29/00 ,  A61P37/06

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开了用类固醇，NSAID和/或腺苷三磷酸酶（“ATPase”）调节剂治疗耳部疾病的组合物和方法。 在这些方法中，通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中，将甾体，NSAID和/或ATP酶组合物和制剂局部施用于患有耳科疾病的个体。

公开(公告)号：US20110319374A1

公开(公告)日：2011-12-29

申请号：US13190327

申请日：2011-07-25

申请人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Durón ,  Michael Christopher Scaife ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Andrew M. Trammel ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Durón ,  Michael Christopher Scaife ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Carl Lebel ,  Andrew M. Trammel ,  Jeffrey P. Harris

IPC分类号： A61K31/573 ,  A61P27/16

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/573 ,  A61K45/06 ,  A61K47/10

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

公开(公告)号：US08496957B2

公开(公告)日：2013-07-30

申请号：US12504553

申请日：2009-07-16

申请人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Duron ,  Carl Lebel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Andrew M. Trammel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Duron ,  Carl Lebel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Andrew M. Trammel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

IPC分类号： A61K9/14 ,  A61K31/47 ,  A61K31/517

CPC分类号： A61K31/517 ,  A61K9/0046 ,  A61K31/135 ,  A61K31/137 ,  A61K31/4535 ,  A61K31/47 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34

摘要： Disclosed herein are methods for the treatment of otic diseases or conditions with intratympanic compositions and formulations of multiparticulate auris sensory cell modulating agent administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开的方法是通过将这些组合物和制剂直接施用于灌注或通过灌注而经由鼓室内组合物和多颗粒耳感觉细胞调节剂的制剂局部施用于患有耳科疾病或病症的个体的耳科疾病或病症的方法 目标耳结构。

公开(公告)号：US20090325938A1

公开(公告)日：2009-12-31

申请号：US12494156

申请日：2009-06-29

申请人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Duron ,  Carl Lebel ,  Fabrice PIU ,  Qiang Ye ,  Luis A. Dellamary ,  Andrew M. Trammel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Duron ,  Carl Lebel ,  Fabrice PIU ,  Qiang Ye ,  Luis A. Dellamary ,  Andrew M. Trammel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

IPC分类号： A61K31/5517 ,  A61K31/5513 ,  A61K31/164

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/00 ,  A61K31/167 ,  A61K31/195 ,  A61K31/197 ,  A61K31/5513 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44 ,  A61K2300/00

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

摘要翻译： 本文公开的是通过将CNS调节剂组合物和组合物局部施用于患有耳科疾病的个体，通过将这些组合物和组合物直接施用到或经由灌注到目标耳结构中来治疗耳部疾病的组合物和方法， 。

公开(公告)号：US10092580B2

公开(公告)日：2018-10-09

申请号：US12506091

申请日：2009-07-20

申请人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Duron ,  Carl Lebel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Andrew M. Trammel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

发明人： Jay Lichter ,  Benedikt Vollrath ,  Sergio G. Duron ,  Carl Lebel ,  Fabrice Piu ,  Qiang Ye ,  Luis A. Dellamary ,  Andrew M. Trammel ,  Michael Christopher Scaife ,  Jeffrey P. Harris

IPC分类号： A61K31/663 ,  A61K47/34 ,  A61K9/00 ,  A61K31/5513 ,  A61K38/17 ,  A61K38/29 ,  A61K38/39 ,  A61K38/47 ,  A61K38/48 ,  A61K31/66

摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).