公开(公告)号：US20060269532A1

公开(公告)日：2006-11-30

申请号：US11344932

申请日：2006-02-01

申请人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

发明人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.