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公开(公告)号：US20070154915A1
公开(公告)日：2007-07-05
申请号：US11591470
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in large intestine cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在大肠癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20070161018A1
公开(公告)日：2007-07-12
申请号：US11591482
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in bile duct cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在胆管癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20080108061A1
公开(公告)日：2008-05-08
申请号：US11591487
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
CPC分类号： C12N15/113 , A61K38/00 , A61K48/005 , C12N15/86 , C12N2310/11 , C12N2760/18843 , C12Q1/6886 , C12Q2600/112
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in brain tumor as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测细胞癌变和癌症恶性程度的指标的癌症相关基因，以提供使用癌症相关基因作为指标检测癌症的方法，以及 提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现了与正常细胞相比在脑肿瘤中扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些癌症相关基因中的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20070161019A1
公开(公告)日：2007-07-12
申请号：US11591637
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in lung cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在肺癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20080312093A1
公开(公告)日：2008-12-18
申请号：US11591489
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in gastric carcinoma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测细胞癌变和癌症恶性程度的指标的癌症相关基因，以提供使用癌症相关基因作为指标检测癌症的方法，以及 提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在胃癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些癌症相关基因中的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20080032943A1
公开(公告)日：2008-02-07
申请号：US11591469
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in thyroid carcinoma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在甲状腺癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些癌症相关基因中的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20080015160A1
公开(公告)日：2008-01-17
申请号：US11591480
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in pancreatic carcinoma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在胰腺癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20070154916A1
公开(公告)日：2007-07-05
申请号：US11591486
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in myeloma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经发现与正常细胞相比在骨髓瘤中扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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