公开(公告)号：US20230119862A1

公开(公告)日：2023-04-20

申请号：US17907188

申请日：2021-03-19

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Gyu PARK ,  Jayeon SONG ,  Hyo Yong KIM ,  Yujin JUNG

IPC: C12Q1/6876 ,  C12Q1/686

Abstract: The present invention relates to a self-priming hairpin-mediated isothermal amplification (SP-HAMP) and, more specifically, to a hairpin probe having a self-priming structure, which is for detecting a target nucleic acid and can be used in the nucleic acid isothermal amplification, and to a method for detecting a target nucleic acid by using same. The SP-HAMP technique according to the present invention is convenient due to no need of a separate primer with a complicated design required in existing LAMP technology, has improved efficiency of detection compared with existing LAMP reactions, and can detect DNA as well as RNA as a target nucleic acid, and therefore the technique according to the present invention can be applied in a wider variety of fields.

公开(公告)号：US20230129651A1

公开(公告)日：2023-04-27

申请号：US17842891

申请日：2022-06-17

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Gyu PARK ,  Yoosik KIM ,  HANSOL KIM ,  Jayeon SONG ,  JunHyeok YOON

IPC: C12N15/113 ,  A61P35/00

Abstract: This application pertains to a hairpin nucleic acid molecule capable of modulating expression of a target gene and a use thereof. A nucleic acid molecule according to an embodiment can modulate expression of a target gene in a specific manner for cells in which a miRNA hybridizable therewith is present, finding advantageous applications in compositions for regulating expression of a target gene or pharmaceutical compositions for treating diseases.