公开(公告)号：US20230002485A1

公开(公告)日：2023-01-05

申请号：US17299156

申请日：2020-12-04

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： In Gyu KIM ,  Rae Kwon KIM ,  Jai Ha LEE ,  Chang Kyu HEO ,  Yeon Jee KAHM ,  Byung Chul SHIN ,  Eun Wie CHO ,  Chun Jeih RYU ,  Min Kyu KIM ,  Mun Ju CHOI

IPC: C07K16/28 ,  A61P35/00 ,  A61P11/00

Abstract: The present invention relates to novel antibodies or antigen-binding fragments thereof that specifically bind to TransMembrane 4 Superfamily Member 4 (TM4SF4). These antibodies or antigen-binding fragments thereof exhibit proliferation inhibitory activity of cancer cells so as to effectively prevent or treat cancer, and reduce the self-renewal ability of cancer stem cells to be usefully used even in the treatments of cancer with a poor prognosis in conventional anticancer treatments.

公开(公告)号：US20240288436A1

公开(公告)日：2024-08-29

申请号：US18571623

申请日：2022-06-16

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE ,  INDUSTRY ACADEMY COOPERATION FOUNDATION OF SEJONG UNIVERSITY

Inventor： In Gyu KIM ,  Chun Jeih RYU ,  Min Kyu KIM ,  Rae Kwon KIM ,  Hwangseo PARK ,  Mun Ju CHOI ,  Yeon Jee KAHM ,  Byung Chul SHIN ,  U Hee JUNG

IPC: G01N33/574 ,  C07K16/28

CPC classification number: G01N33/57492 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to an anti-TM4SF4 (TransMembrane 4 Superfamily Member 4) humanized antibody and use thereof. The anti-TM4SF4 humanized antibody of present invention has high affinity for binding specifically to TM4SF4 while exhibiting low immunogenicity in humans, and thus can be advantageously used to detect TM4SF4 or to target cancer cells and cancer stem cells that overexpress TM4SF4.