公开(公告)号：US20230002485A1

公开(公告)日：2023-01-05

申请号：US17299156

申请日：2020-12-04

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： In Gyu KIM ,  Rae Kwon KIM ,  Jai Ha LEE ,  Chang Kyu HEO ,  Yeon Jee KAHM ,  Byung Chul SHIN ,  Eun Wie CHO ,  Chun Jeih RYU ,  Min Kyu KIM ,  Mun Ju CHOI

IPC: C07K16/28 ,  A61P35/00 ,  A61P11/00

Abstract: The present invention relates to novel antibodies or antigen-binding fragments thereof that specifically bind to TransMembrane 4 Superfamily Member 4 (TM4SF4). These antibodies or antigen-binding fragments thereof exhibit proliferation inhibitory activity of cancer cells so as to effectively prevent or treat cancer, and reduce the self-renewal ability of cancer stem cells to be usefully used even in the treatments of cancer with a poor prognosis in conventional anticancer treatments.