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公开(公告)号：US20210246112A1
公开(公告)日：2021-08-12
申请号：US16958794
申请日：2018-07-23
Inventor： Joung Han YIM , II-Chan KIM , Se Jong HAN , Ui Joung YOUN , Hong Kum LEE , Jun Hyuck LEE , Tai Kyoung KIM , Kwon Joo YEO
IPC: C07D307/88
Abstract: The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.
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