公开(公告)号：US10035795B1

公开(公告)日：2018-07-31

申请号：US15480839

申请日：2017-04-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo Roh ,  Bo Ra Mi Jeon ,  Chang Joon Lee ,  Jin Pyo Hong ,  Joo Yeon Jeong ,  Sang Soo Kang

IPC: C07D417/06 ,  C07D279/28

CPC classification number: C07D417/06 ,  C07D279/28

Abstract: The present invention provides a phenothiazine derivative or a pharmaceutically acceptable salt thereof, a method of preparing a compound selected therefrom and a pharmaceutical composition containing the compound as an active ingredient. The phenothiazine derivative according to the present invention has an effect of inhibiting calmodulin (CaM; calcium-modulated protein) and thus helps cell death by maintaining the intracellular level of calcium in lung cancer cells at high concentration. Accordingly, the phenothiazine derivative according to the present invention can be usefully used to prevent or treat malignant tumors such as lung cancer.