公开(公告)号：US20190211032A1

公开(公告)日：2019-07-11

申请号：US16315263

申请日：2017-07-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gamal El-din MAHMOUD ,  Hong Seok CHOI ,  Kyung Ho YOO ,  Dong Keun HAN ,  Chang Hyun OH ,  Abdel-Maksoud MOHAMMED ,  I. El-Gamal MOHAMMED

IPC: C07D513/04 ,  C07D498/04 ,  A61P35/00

Abstract: Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.

公开(公告)号：US20190315726A1

公开(公告)日：2019-10-17

申请号：US16362571

申请日：2019-03-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Ha LEE ,  Kyung Ho YOO ,  Eun Joo ROH ,  Tae Bo SIM ,  Tae Young KIM ,  Jae Ho KIM

IPC: C07D405/14 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/48 ,  A61P35/00 ,  A61P25/28 ,  A61P37/02 ,  A61P29/00

Abstract: Disclosed are a novel pyrimidine derivative compound, a pharmaceutically acceptable salt thereof, a method for preparing the compound and a pharmaceutical use of the compound as an anticancer agent or a therapeutic agent for degenerative brain diseases. Specifically, the novel pyrimidine derivative compound has excellent inhibitory activities against kinase enzymes such as ARK5/NUAK1, ACK1, FLT3, JAK1, JAK2 and JAK2 (V617F) and thus is useful for treating and preventing leukemia, ovarian cancer, breast cancer, non-small cell carcinoma, colorectal cancer, glioma, and brain protein abnormalities such as Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia, that is, degenerative diseases caused by Tau deposition.