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公开(公告)号：US20210238151A1
公开(公告)日：2021-08-05
申请号：US17145357
申请日：2021-01-10
Applicant: KUWAIT UNIVERSITY
IPC: C07D263/06 , A61P37/08 , A61P11/06
Abstract: Oxazolidione hydroxamic acid derivatives of the general formula (I): where R1 is hydrogen or hexanoyl and R2 is amino, methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, isobutyl, cyclobutyl, pentyl, cyclopentyl, hexyl or heptyl, and pharmaceutically acceptable salts thereof, act as dual inhibitors of 5-lipoxygenase and mast cell degranulation. The oxazolidinone hydroxamic acid derivatives or pharmaceutically acceptable salts thereof can be used in the prevention and treatment of asthma and allergies, as well as inflammatory conditions.
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