公开(公告)号：US5973208A

公开(公告)日：1999-10-26

申请号：US78502

申请日：1998-05-14

申请人： Katsushi Nagareda ,  Yoshihiro Tokuda ,  Shigeaki Suzuki

发明人： Katsushi Nagareda ,  Yoshihiro Tokuda ,  Shigeaki Suzuki

IPC分类号： C07C209/26 ,  C07C211/09

CPC分类号： C07C209/26

摘要： A process for producing diamines by reacting a dialdehyde with ammonia and hydrogen in the presence of a hydrogenation catalyst to produce the corresponding diamine, where a solvent comprising an alcohol is used in the reaction and the concentration of water in the reaction mixture is 5 to 15% by weight.

摘要翻译： 一种通过在加氢催化剂存在下使二醛与氨和氢反应制备二胺的方法，以产生相应的二胺，其中在反应中使用包含醇的溶剂，反应混合物中的水浓度为5至15 重量％。

公开(公告)号：US08039645B2

公开(公告)日：2011-10-18

申请号：US12529548

申请日：2008-03-05

申请人： Junichi Fuji ,  Shigeru Okano ,  Katsushi Nagareda

发明人： Junichi Fuji ,  Shigeru Okano ,  Katsushi Nagareda

IPC分类号： C07D307/02

CPC分类号： C07D307/28 ,  Y02P20/582

摘要： The method of the invention for continuously producing 2,5-dihydrofuran includes subjecting cis-2-butene-1,4-diol to liquid-phase dehydration-cyclization reaction in the presence of alumina, characterized in that the sum of the concentration of carbonyl compounds present in the reaction system and the concentration of acetal compounds present in the reaction system is controlled to fall within a range of 0.1 to 2 mol/L, provided that the concentration of the acetal compounds is calculated in terms of acetal groups, the concentrations being determined on the basis of the total amount of the reaction mixture. According to the method, 2,5-dihydrofuran, which is useful as a raw material or intermediate for producing pharmaceuticals, agrochemicals, raw materials of polymers, etc., can be continuously produced. The method can prevent inactivation of γ-alumina and is advantageous for long-term production on an industrial scale.

摘要翻译： 本发明连续生产2,5-二氢呋喃的方法包括在氧化铝存在下使顺式-2-丁烯-1,4-二醇进行液相脱水 - 环化反应，其特征在于羰基的浓度之和 存在于反应体系中的化合物和反应体系中存在的缩醛化合物的浓度控制在0.1至2mol / L的范围内，条件是缩醛化合物的浓度以缩醛基计算，浓度 基于反应混合物的总量确定。 根据该方法，可以连续制造可用作生产药物，农药，聚合物原料等的原料或中间体的2,5-二氢呋喃。 该方法可以防止γ-氧化铝的失活，对于工业规模的长期生产是有利的。

公开(公告)号：US06331650B1

公开(公告)日：2001-12-18

申请号：US09630608

申请日：2000-08-02

申请人： Jin Tokuyasu ,  Koichiro Isoue ,  Katsushi Nagareda ,  Takashi Onishi

发明人： Jin Tokuyasu ,  Koichiro Isoue ,  Katsushi Nagareda ,  Takashi Onishi

IPC分类号： C07C21100

CPC分类号： C07C213/02 ,  C07C215/08 ,  C07C215/12 ,  C07D307/22 ,  C07D309/14

摘要： An aminoalcohol is synthesized by reacting a cyclic hemiacetal expressed by Formula 1 (where n is 0 or 1; R1 and R2 are each a hydrogen atom, a monovalent saturated hydrocarbon group which is optionally substituted, or a monovalent aromatic group which is optionally substituted, or R1 and R2 are bonded together into a divalent saturated hydrocarbon group which is optionally substituted; and R3, R4, and R5 are each a hydrogen atom, a monovalent saturated hydrocarbon group which is optionally substituted, or a monovalent aromatic group which is optionally substituted), with hydrogen and any one of ammonia, a primary amine and secondary amine in the presence of a hydrogenation catalyst.

摘要翻译： 通过使由式1（其中n为0或1; R 1和R 2各自为氢原子，任选取代的一价饱和烃基或任选取代的一价芳族基团）的环状半缩醛反应合成氨基醇， 或R 1和R 2结合成为任选被取代的二价饱和烃基; R 3，R 4和R 5各自为氢原子，任选取代的一价饱和烃基或任选取代的一价芳族基 ）与氢气和氨，伯胺和仲胺中的任一种在氢化催化剂存在下反应。

公开(公告)号：US20100087665A1

公开(公告)日：2010-04-08

申请号：US12529548

申请日：2008-03-05

申请人： Junichi Fuji ,  Shigeru Okano ,  Katsushi Nagareda

发明人： Junichi Fuji ,  Shigeru Okano ,  Katsushi Nagareda

IPC分类号： C07D307/02

CPC分类号： C07D307/28 ,  Y02P20/582

摘要： The method of the invention for continuously producing 2,5-dihydrofuran includes subjecting cis-2-butene-1,4-diol to liquid-phase dehydration-cyclization reaction in the presence of alumina, characterized in that the sum of the concentration of carbonyl compounds present in the reaction system and the concentration of acetal compounds present in the reaction system is controlled to fall within a range of 0.1 to 2 mol/L, provided that the concentration of the acetal compounds is calculated in terms of acetal groups, the concentrations being determined on the basis of the total amount of the reaction mixture. According to the method, 2,5-dihydrofuran, which is useful as a raw material or intermediate for producing pharmaceuticals, agrochemicals, raw materials of polymers, etc., can be continuously produced. The method can prevent inactivation of γ-alumina and is advantageous for long-term production on an industrial scale.

摘要翻译： 本发明连续生产2,5-二氢呋喃的方法包括在氧化铝存在下使顺式-2-丁烯-1,4-二醇进行液相脱水 - 环化反应，其特征在于羰基的浓度之和 存在于反应体系中的化合物和反应体系中存在的缩醛化合物的浓度控制在0.1至2mol / L的范围内，条件是缩醛化合物的浓度以缩醛基计算，浓度 基于反应混合物的总量确定。 根据该方法，可以连续制造可用作生产药物，农药，聚合物原料等的原料或中间体的2,5-二氢呋喃。 该方法可以防止γ-氧化铝的失活，对于工业规模的长期生产是有利的。