公开(公告)号：US20190382476A1

公开(公告)日：2019-12-19

申请号：US16425551

申请日：2019-05-29

Applicant: Korea Basic Science Institute

Inventor： Ik Soon Jang ,  Kyung Bok Lee ,  Hyun Jin Jang

IPC: C07K16/28 ,  A61P3/10

Abstract: There is provided a method for treating diabetes in a subject in need thereof, the method comprising administering to the subject a composition comprising a tetraspanin-2 (TSPAN2) protein activity inhibitor as an active ingredient in an amount effective for treating diabetes

公开(公告)号：US10451635B2

公开(公告)日：2019-10-22

申请号：US15339773

申请日：2016-10-31

Applicant: Korea Basic Science Institute

Inventor： Ik Soon Jang ,  Jong Soon Choi ,  Joseph Kwon ,  Dong-Gi Lee ,  Kyeong Eun Yang

IPC: G01N33/68 ,  C07K16/18

Abstract: The present invention relates to a beef-specific age determination marker containing the p21 protein, to an antibody specifically bound to bovine p21 protein, to a beef-specific age determination kit containing the antibody which is specifically bound to the bovine p21 protein, and to a method which involves detecting the bovine p21 protein through an antigen-antibody binding reaction using the antibody which is specifically bound to the bovine p21 protein serving as a beef-specific age determination marker in the muscle tissue of beef, so as to determine the age of the beef. According to the present invention, the p21 protein is significantly greatly expressed in the muscle tissue of beef, the age of which is lower than 30 months, and is hardly expressed in the muscle tissue of beef, the age of which is greater than 30 months, and thus can be valuably used as a beef-specific age determination marker.

公开(公告)号：US20180085421A1

公开(公告)日：2018-03-29

申请号：US15609605

申请日：2017-05-31

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Ik Soon Jang ,  Kyung Bok Lee ,  Hyun Jin Jang

IPC: A61K38/07 ,  A61K38/00 ,  G01N33/487 ,  G01N33/50 ,  G01N33/68

CPC classification number: A61K38/07 ,  A61K38/005 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/487 ,  G01N33/50 ,  G01N33/5008 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/042

Abstract: There is provided a method for treating diabetes, the method comprising administering to a subject in need thereof an effective amount of a tetraspanin-2 (TSPAN2) protein expression or activity inhibitor. Further, there is provided a method for screening a diabetes therapeutic agent, the method comprising: (a) bringing a test material into contact with a cell expressing TSPAN2 gene; (b) determining the expression level of the TSPAN2 gene in the cell of (a) and in a control cell which is not in contact with the test material; and (c) selecting, as a diabetes therapeutic agent candidate, the test material reducing the expression level of the TSPAN2 gene in comparison with the control cell.