公开(公告)号：US20240398809A1

公开(公告)日：2024-12-05

申请号：US18405453

申请日：2024-01-05

Applicant: LEO PHARMA A/S ,  Japan Tobacco Inc.

Inventor： Michael SIERRA ,  Tord LABUDA ,  Atsuo TANIMOTO ,  Yuichi SHINOZAKI

IPC: A61K31/519 ,  A61K9/00 ,  A61K9/06 ,  A61K47/06 ,  A61P17/14

Abstract: The present invention provides a novel treatment of alopecia areate. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-ox-opropanenitrile. A therapeutic or preventive agent for alopecia areata, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro-[3.4]octan-1-yl]-3-oxopropanenitrile as an active ingredient.

公开(公告)号：US20180263986A1

公开(公告)日：2018-09-20

申请号：US15762188

申请日：2016-09-22

Applicant: LEO Pharma A/S ,  Japan Tobacco Inc.

Inventor： Michael SIERRA ,  Tord LABUDA ,  Atsuo TANIMOTO ,  Yuichi SHINOZAKI

IPC: A61K31/519 ,  A61P17/14 ,  A61K9/00

CPC classification number: A61K31/519 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/06 ,  A61P17/14

Abstract: The present invention provides a novel treatment of alopecia areate. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent for alopecia areata, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile as an active ingredient.

公开(公告)号：US20220088020A1

公开(公告)日：2022-03-24

申请号：US17228831

申请日：2021-04-13

Applicant: LEO PHARMA A/S ,  Japan Tobacco Inc.

Inventor： Michael SIERRA ,  Tord LABUDA ,  Atsuo TANIMOTO ,  Yuichi SHINOZAKI

IPC: A61K31/519 ,  A61K9/00 ,  A61K47/06 ,  A61K9/06 ,  A61P17/14

Abstract: The present invention provides a novel treatment of alopecia areate. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent for alopecia areata, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile as an active ingredient.