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公开(公告)号：US20210398615A1
公开(公告)日：2021-12-23
申请号：US16899545
申请日：2020-06-11
Applicant: Life Technologies Corporation
Inventor： Yong Chu , Stephanie Jo Schneider , Rylan Schaeffer , David Woo
Abstract: A method of automatically sequencing or basecalling one or more DNA (deoxyribonucleic acid) molecules of a biological sample is described. The method comprises using a capillary electrophoresis genetic analyzer to measure the biological sample to obtain at least one input trace comprising digital data corresponding to fluorescence values for a plurality of scans. Scan labelling probabilities for the plurality of scans are generated using a trained artificial neural network comprising a plurality of layers including convolutional layers. A basecall sequence comprising a plurality of basecalls for the one or more DNA molecules based on the scan labelling probabilities for the plurality of scans is determined.
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公开(公告)号：US11664090B2
公开(公告)日：2023-05-30
申请号：US16899545
申请日：2020-06-11
Applicant: Life Technologies Corporation
Inventor： Yong Chu , Stephanie Jo Schneider , Rylan Schaeffer , David Woo
CPC classification number: G16B30/00 , C12Q1/6869 , G06K9/6201 , G06K9/623 , G06K9/6256 , G06K9/6277 , G06N3/084 , G06N5/046 , G16B25/00 , G16B40/00
Abstract: A method of automatically sequencing or basecalling one or more DNA (deoxyribonucleic acid) molecules of a biological sample is described. The method comprises using a capillary electrophoresis genetic analyzer to measure the biological sample to obtain at least one input trace comprising digital data corresponding to fluorescence values for a plurality of scans. Scan labelling probabilities for the plurality of scans are generated using a trained artificial neural network comprising a plurality of layers including convolutional layers. A basecall sequence comprising a plurality of basecalls for the one or more DNA molecules based on the scan labelling probabilities for the plurality of scans is determined.
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