公开(公告)号：US20070141081A1

公开(公告)日：2007-06-21

申请号：US11705696

申请日：2007-02-13

申请人： Lisset Cruz ,  Rayner Diaz ,  Laura Vazquez ,  Aida Morales ,  Carlos Abarrategui ,  Iris Prado ,  Ricardo Silva Rodriguez ,  Glay Santiago ,  Gerardo Guillen Nieto ,  Maria Guzman Tirado ,  Beatriz de la Sierra Vazquez ,  Raul Espinosa Perez

发明人： Lisset Cruz ,  Rayner Diaz ,  Laura Vazquez ,  Aida Morales ,  Carlos Abarrategui ,  Iris Prado ,  Ricardo Silva Rodriguez ,  Glay Santiago ,  Gerardo Guillen Nieto ,  Maria Guzman Tirado ,  Beatriz de la Sierra Vazquez ,  Raul Espinosa Perez

IPC分类号： C12P19/34 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N2770/24122 ,  Y02A50/386

摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.

摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。

公开(公告)号：US20060193853A1

公开(公告)日：2006-08-31

申请号：US10539172

申请日：2003-12-22

申请人： Eddy Fuentes ,  Roberto Baker ,  Eulogio Vazquez ,  Jesus Barranco ,  Franklin Aguilar ,  Niurka More ,  Lesvia Aguilera ,  Hector Dominguez ,  Yovisleidys Saez ,  Gerardo Guillen Nieto ,  Glay Santiago

发明人： Eddy Fuentes ,  Roberto Baker ,  Eulogio Vazquez ,  Jesus Barranco ,  Franklin Aguilar ,  Niurka More ,  Lesvia Aguilera ,  Hector Dominguez ,  Yovisleidys Saez ,  Gerardo Guillen Nieto ,  Glay Santiago

IPC分类号： A61K39/395 ,  A61K38/24 ,  A61K38/25 ,  A61K38/17

CPC分类号： A61K39/0011 ,  A61K39/395 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6081

摘要： The invention relates to the field of immunology, endocrinology and oncology and, in particular, the generation of a combined immune response to determined growth factors and hormones. A synergic effect, outlined herein, between growth regulating factors (EGF, TGF and VEGF) and hormones involved in the sexual hormones release cascade or reproduction (GnRH, LH, FSH) stimulates the anti-tumor response which is expressed as a reduction in the tumor mass and an increase in the survival time.

摘要翻译： 本发明涉及免疫学，内分泌学和肿瘤学领域，特别是对确定的生长因子和激素的组合免疫应答的产生。 生长调节因子（EGF，TGF和VEGF）和参与性激素释放级联或繁殖（GnRH，LH，FSH）的激素之间的协同作用刺激抗肿瘤反应，其表达为 肿瘤块和生存时间增加。