公开(公告)号：US20150167004A1

公开(公告)日：2015-06-18

申请号：US14413004

申请日：2013-07-09

Applicant: METHEOR THERAPEUTICS CORPORATION

Inventor： Andrew Z. Sledziewski ,  Theodore Devos ,  Ryszard Kole

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  C12N2310/13 ,  C12N2310/33 ,  C12N2310/3341 ,  C12N2310/531 ,  C12Y201/01037

Abstract: Modified oligonucleotides comprising CpG sites, wherein the cytosine is replaced by cytosine analogs are provided as well as methods of making the oligonucleotides and their use in inhibiting DNA Methyltransferase, inhibiting or reversing methylation of genes and in treating cancer, tumorigenesis and hyper-proliferative disorders.

Abstract translation: 提供了包含CpG位点的修饰的寡核苷酸，其中胞嘧啶被胞嘧啶类似物替代，以及制备寡核苷酸及其在抑制DNA甲基转移酶中的用途，抑制或逆转基因甲基化和治疗癌症，肿瘤发生和高增殖性疾病的方法。