公开(公告)号：US20240391878A1

公开(公告)日：2024-11-28

申请号：US18657572

申请日：2024-05-07

Applicant: MOEHS IBERICA, S.L.

Inventor： Ronnie Andrés MIRANDA ,  Albert COROMINAS ,  Isabel LLOVERAS ,  Juan Pablo BAYÓN RUEDA

IPC: C07D233/60 ,  B01J31/22 ,  C07D233/58

Abstract: A method is for preparing dexmedetomidine ((S)-4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole) or a pharmaceutically acceptable salt and/or solvate thereof via the asymmetric hydrogenation of a methylene derivative. Methods for preparing tert-butyl (S)-4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole-1-carboxylate or a pharmaceutically acceptable salt and/or solvate thereof are vuseful in the preparation of dexmedetomidine or its salts. The catalyst can be rhodium (I) bis(2,5-norbornadiene)tetrafluoroborate (IVa) in the method.