公开(公告)号：US09861623B1

公开(公告)日：2018-01-09

申请号：US15337293

申请日：2016-10-28

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  David Ward ,  Elaine Lai-Han Leung ,  Xiao Jun Yao ,  Vincent Kam-Wai Wong ,  Lian-Xiang Luo

IPC: A61K31/454 ,  A61K31/52

CPC classification number: A61K31/454 ,  A61K31/52 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides methods for treatment of a RAS-positive disease, in particular KRAS-positive non-small cell lung cancer as well as a method for potentiating the apoptotic activity of a PDEδ inhibitor by combining the PDEδ inhibitor with a direct autophagy inhibitor. The PDEδ inhibitor is preferably, but not exclusively, deltarasin, and the direct autophagy inhibitor is in particular 3-methyladenine. Further provided by the present invention are a kit and a pharmaceutical composition comprising the PDEδ inhibitor and a direct autophagy inhibitor. The methods of the present invention in particular provide a new treatment option for RAS-positive diseases such as KRAS-positive non-small cell lung cancer allowing for an increased apoptotic activity of the PDEδ inhibitor by simultaneously blocking its “tumor protective” autophagy.