公开(公告)号：US20180289666A1

公开(公告)日：2018-10-11

申请号：US15481720

申请日：2017-04-07

Applicant: Macau University of Science and Technology

Inventor： Ying Xie ,  Liang Liu ,  Hua Zhou ,  Zhong-Wen Yuan ,  Yan-Fang Zheng ,  Sen-Ling Feng ,  Xiao-Hui Zeng ,  Hui Wang

IPC: A61K31/366

Abstract: A method for reducing abnormalities in lipid metabolism and for reducing inflammation in a subject suffering from an autoimmune inflammatory disease accompanied by abnormalities in lipid metabolism includes administering an effective amount of a flavonolignan to the subject. The subject may additionally suffer from a liver disease, obesity, hypertension, diabetes mellitus or a metabolic syndrome. Further provided is a method for reducing the risk of a cardiovascular disease in a subject suffering from an autoimmune inflammatory disease accompanied by abnormalities in lipid metabolism and a method for reducing hepatic abnormalities and reducing inflammation in a subject suffering from an autoimmune inflammatory disease accompanied by hepatic abnormalities. Still further provided is a method for reducing liver damages associated with the treatment of rheumatoid arthritis with a disease-modifying antirheumatic drug or a non-steroidal anti-inflammatory drug.