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公开(公告)号:US20080161592A1
公开(公告)日:2008-07-03
申请号:US12043872
申请日:2008-03-06
申请人: Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , William Patt , Maher Qabar , Lauri Marie Schultz , Feng Hong , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffrey Howbert
发明人: Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , William Patt , Maher Qabar , Lauri Marie Schultz , Feng Hong , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffrey Howbert
CPC分类号: C07F9/6541 , C07F9/3808 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/65517
摘要: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
摘要翻译: 本发明提供了可用于调节蛋白酪氨酸磷酸酶-1b(PTP1B)酶的生物学活性的式(I)和式(II)的化合物。 本发明的化合物可用于治疗其中PTP1B酶是因子的疾病和/或病症。 这些疾病和/或病症包括但不限于1型糖尿病,2型糖尿病,葡萄糖耐量不足,胰岛素抵抗,肥胖症,高脂血症,高甘油三酯血症,高胆固醇血症,低HDL水平,动脉粥样硬化,血管再狭窄,炎性肠病, 胰腺炎,脂肪细胞瘤,脂肪细胞癌,脂肪肉瘤,血脂异常,癌症和神经变性疾病。