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公开(公告)号：US08546369B2
公开(公告)日：2013-10-01
申请号：US12229955
申请日：2008-08-28
申请人： Marvin Heuer , Michele Molino , Joseph MacDougall
发明人： Marvin Heuer , Michele Molino , Joseph MacDougall
IPC分类号： A61K31/33 , A61K31/435 , A61K31/155
CPC分类号： C07D211/40 , A23L33/175 , C07D207/12 , C07D223/08 , Y02P20/55
摘要： The present invention relates to stable salts of creatine imino sugar amides and an inorganic or organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral and parenteral administration. Methods of preparation and use of these compositions are also provided.
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2.发明申请公开(公告)号：US20090069422A1
公开(公告)日：2009-03-12
申请号：US11853277
申请日：2007-09-11
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
CPC分类号： A61K31/22 , A61K2300/00
摘要： A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one α-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.
摘要翻译： 本发明提供了至少包含治疗有效量的丙酮酸乙酯和治疗有效量的至少一种α-羟基支链氨基酸代谢物的营养补充剂。 本发明的营养补充剂的成分通过基本上同时维持血液和肌肉生理pH水平以及增加支链氨基酸的细胞浓度而基本上同时作用于诱导肌肉的合成代谢状态。 本公开提供了组合物和方法。
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3.发明授权公开(公告)号：US07645794B2
公开(公告)日：2010-01-12
申请号：US11853277
申请日：2007-09-11
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/225 , A61K31/20
CPC分类号： A61K31/22 , A61K2300/00
摘要： A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one α-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.
摘要翻译： 本发明提供了至少包含治疗有效量的丙酮酸乙酯和治疗有效量的至少一种α-羟基支链氨基酸代谢物的营养补充剂。 本发明的营养补充剂的成分通过基本上同时维持血液和肌肉生理pH水平以及增加支链氨基酸的细胞浓度而基本上同时作用于诱导肌肉的合成代谢状态。 本公开提供了组合物和方法。
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4.发明申请Preparations containing pyridoxine and alpha-hydroxyisocaproic acid (HICA) 审中-公开含有吡哆醇和α-羟基异己酸（HICA）的制剂公开(公告)号：US20090156648A1
公开(公告)日：2009-06-18
申请号：US11954652
申请日：2007-12-12
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/4412 , C07D211/90
CPC分类号： C07D213/67
摘要： The present invention relates to stable salts of pyridoxine and α-hydroxyisocaproic acid (HICA) endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.
摘要翻译： 本发明涉及具有与其各自作用有关的增强的营养和/或治疗功效的吡哆醇和α-羟基异己酸（HICA）的稳定盐，以及含有特别适合于口服给药的盐的固体组合物。 还提供了一种制备方法。
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5.发明申请COMPOSITIONS AND METHODS FOR ENHANCING PROTEIN ACCRETION IN SKELETAL MUSCLE 审中-公开用于增强骨骼肌肉蛋白质摄取的组合物和方法公开(公告)号：US20090163573A1
公开(公告)日：2009-06-25
申请号：US11962948
申请日：2007-12-21
IPC分类号： A61P21/00 , A61K31/385 , A61K31/195
CPC分类号： A61K31/198 , A61K31/195 , A61K31/385 , A61K2300/00
摘要： A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and an effective amount of glutamine or derivative of glutamine, wherein the ingredients act substantially simultaneously to increase protein synthesis and inhibit protein degradation in skeletal muscle, via enhanced expression of heat shock proteins in cells, particularly heat shock protein 72. A method of same is also provided.
摘要翻译： 一种营养组合物，其包含至少有效量的香叶基香叶基丙酮或前列腺素基丙酮衍生物和有效量的谷氨酰胺或谷氨酰胺衍生物，其中所述成分基本上同时作用，通过增强的热休克表达来增加蛋白质合成和抑制骨骼肌中的蛋白质降解 细胞中的蛋白质，特别是热休克蛋白72.还提供了其方法。
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公开(公告)号：US20090156676A1
公开(公告)日：2009-06-18
申请号：US11954644
申请日：2007-12-12
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/195 , C07C229/04
CPC分类号： C07C229/08
摘要： The present invention relates to stable salts of β-alanine and an organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.
摘要翻译： 本发明涉及β-丙氨酸的稳定盐和赋予其对各自作用的增强的营养和/或治疗功效的有机酸，以及含有特别适合于口服给药的盐的固体组合物。 还提供了一种制备方法。
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7.发明申请Method for maintaining physiological pH levels during intensive physical exercise 审中-公开在强力运动时保持生理pH值的方法公开(公告)号：US20090156647A1
公开(公告)日：2009-06-18
申请号：US11954635
申请日：2007-12-12
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
CPC分类号： A61K31/44
摘要： A nutritional supplement comprising at least a therapeutically effective amount of pyridoxine α-hydroxyisocaproate is provided by the present invention. The ingredients of the present nutritional supplement act substantially simultaneously to maintain physiological blood and muscular pH and increase the time to muscular fatigue in a mammal during periods of repetitive forceful muscular exercise. A method of use is provided by the present disclosure.
摘要翻译： 包含至少治疗有效量的吡哆醇α-羟基异己酸的营养补充剂由本发明提供。 本发明的营养补充剂的成分基本上同时起作用以维持生理性血液和肌肉酸碱度，并且在重复强力肌肉运动期间增加哺乳动物肌肉疲劳的时间。 本公开提供了一种使用方法。
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8.发明申请Tropane alkaloids and trigonelline combinations and methods for administering the same 审中-公开托烷生物碱和葫芦巴酮组合及其施用方法公开(公告)号：US20090156634A1
公开(公告)日：2009-06-18
申请号：US11954662
申请日：2007-12-12
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
IPC分类号： A61K31/44 , A61K31/439 , A61P21/00
CPC分类号： A61K31/439 , A23L33/105 , A23V2002/00 , A61K31/44 , A61K2300/00 , A23V2200/316 , A23V2250/21
摘要： A nutritional composition comprising at least an effective amount of trigonelline or derivative of trigonelline and an effective amount of tropane alkaloids, wherein the ingredients act substantially simultaneously improve the consistency of muscular contractions with respect to applied force and relaxation cycles over time and reduce the onset of central fatigue. A method of same is also provided.
摘要翻译： 营养组合物，其包含至少有效量的葫芦巴碱或葫芦巴衍生物和有效量的托烷生物碱，其中所述成分基本上同时改善随着时间推移施加的力和松弛循环的肌肉收缩的一致性，并减少 中枢疲劳 还提供了其方法。
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公开(公告)号：US08426395B2
公开(公告)日：2013-04-23
申请号：US12229979
申请日：2008-08-28
IPC分类号： A61K31/33 , A61K31/435
CPC分类号： C07D211/40 , A23L33/175 , C07D207/12 , C07D223/08 , Y02P20/55
摘要： Compounds produced by combining imino sugars and creatine are herein disclosed. The compounds being in the form of a creatine imino sugar amides and produced by the disclosed methods; protecting the guanidine group of creatine and then activating the protected creatine with DCC and reacting it with an imino sugar, followed by removal of the guanidine protecting groups. The resulting creatine imino sugar amides have enhanced stability in solution as compared to related esters. In addition, specific benefits are conferred by the imino sugar in addition to, and separate from, the creatine substituent. Methods of preparation and use of these compounds are also disclosed.
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公开(公告)号：US20090270501A1
公开(公告)日：2009-10-29
申请号：US12499109
申请日：2009-07-08
申请人： Michele Molino , Joseph MacDougall
发明人： Michele Molino , Joseph MacDougall
CPC分类号： A61K31/22 , A61K2300/00
摘要： A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one α-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.
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