公开(公告)号：US20070219389A1

公开(公告)日：2007-09-20

申请号：US10592298

申请日：2005-03-07

申请人： Masaaki Miyashita ,  Keiji Tanino ,  Yoshihide Tomata ,  Yasuhiro Shiina

发明人： Masaaki Miyashita ,  Keiji Tanino ,  Yoshihide Tomata ,  Yasuhiro Shiina

IPC分类号： C07C253/30

CPC分类号： C07C253/30 ,  C07C255/47 ,  C07C2602/24 ,  C07C2602/26 ,  C12P13/002 ,  C12P41/00

摘要： [Problems] To provide a process for the synthesis of cyclopentenenitrile derivatives through conjugate addition of a nitrile derivative to an α,β-unsaturated ketone whereby cyclopentenenitrile derivatives, particularly those capable of optical resolution, can be obtained in high yield without expensive reagents or compounds in a decreased number of steps. [Means for Solving Problems] A novel process for the production of cyclopentenenitrile derivatives in high yield, which comprises trapping a compound obtained by conjugate addition of a 4-alkoxy-3-butenenitrile which may have alkyl or allyl at the α-position (e.g., 4-methoxy-3-butenenitrile) to an α,β-unsaturated ketone as an enol ester with acetic anhydride, chlorocarbonic ester, or the like and treating the enol ester with a strong acid or the like to form a five-membered ring.

摘要翻译： [问题]提供通过将腈衍生物偶联加成到α，β-不饱和酮中合成环戊烯腈衍生物的方法，由此可以高产率获得环戊烯腈衍生物，特别是能够进行光学拆分的衍生物，而不需要昂贵的试剂或化合物 减少步数。 [解决问题的手段]以高产率生产环戊烯腈衍生物的新方法，其包括捕获通过在α-位上共轭加成可以具有烷基或烯丙基的4-烷氧基-3-丁烯腈获得的化合物（例如 ，4-甲氧基-3-丁烯腈）与乙酸酐，氯代碳酸酯等作为烯醇酯的α，β-不饱和酮，用强酸等处理烯醇酯以形成五元环 。

公开(公告)号：US06453318B1

公开(公告)日：2002-09-17

申请号：US09349976

申请日：1999-07-09

申请人： Yasuhiro Shiina ,  Masahiro Noguchi

发明人： Yasuhiro Shiina ,  Masahiro Noguchi

IPC分类号： G06F1700

CPC分类号： G06F17/30604 ,  G06F17/30371 ,  Y10S707/99934 ,  Y10S707/99943

摘要： A management apparatus has a structure definition input unit for inputting the structure definition of information, a data definition input unit for inputting a data definition that represents entities of information and the relationship between the entities in accordance with the input structure definition, and a modeling unit for interpreting the input definitions and constraints to convert them into an ER model. Since an ER model can be obtained independently of the formats of input definitions, a user can freely define the structure of information as he or she likes regardless of the complexity of the structure, and need not relate information bidirectionally, and can freely and easily defines the structure of information.

摘要翻译： 管理装置具有用于输入信息的结构定义的结构定义输入单元，用于根据输入结构定义输入表示信息实体的数据定义和实体之间的关系的数据定义输入单元，以及建模单元 用于解释输入定义和约束以将其转换为ER模型。 由于可以独立于输入定义的格式获得ER模型，用户可以自由地定义他或她喜欢的信息结构，而不考虑结构的复杂性，并且不需要双向地关联信息，并且可以自由和容易地定义 信息的结构。